Emerging drugs in lung transplantation

Babith Mankidy, Ramesh B. Kesavan, Yavuz S. Silay, Tarik J. Haddad, Harish Seethamraju

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

The balance between immunosuppression to ensure graft tolerance while preventing emergence of infectious complications is key in lung transplantation. Although opportunistic infection may appear to be the most important of these complications, malignancies and severe drug toxicities significantly affect the short- and long-term outcomes of the patients. The present practice is combination therapy using drugs with complementary immunosuppressive action, to achieve synergistic immunosuppression with the lowest possible toxicity. Components of immunosuppression include induction and maintenance regimens. Primary graft failure remains an important cause of mortality and morbidity in the immediate post-transplant period. Acute rejection is a common complication after lung transplant, but responds well to augmented immunosuppression and immunomodulation. Chronic rejection still is the major cause of mortality in patients who survive the initial year post-transplantation. Several new drugs have shown promise in decreasing the rate of loss of graft function. This review discusses the current and emerging therapeutic regimens.

Original languageEnglish (US)
Pages (from-to)61-73
Number of pages13
JournalExpert Opinion on Emerging Drugs
Volume12
Issue number1
DOIs
StatePublished - Mar 2007
Externally publishedYes

Keywords

  • Acute rejection
  • Chronic rejection
  • Immunosuppressant drugs
  • Immunosuppression
  • Induction regimen
  • Lung transplant
  • Primary graft failure

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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