Elevation of blood Β-carboline alkaloids in essential tremor

Elan D. Louis, W. Zheng, E. C. Jurewicz, D. Watner, J. Chen, P. Factor-Litvak, Michael K. Parides

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

Background: β-Carboline alkaloids are normal body constituents but are also potent tremor-producing chemicals that are naturally present in the food chain. Objective: To explore the hypothesis that high concentrations of β-carboline alkaloids are associated with essential tremor (ET). Methods: One hundred cases and 100 controls were frequency matched on age, sex, and ethnicity. Blood concentrations of harmane and harmine were quantified by high-performance liquid chromatography, blinded to clinical information. Results: The mean log blood concentration of harmane was higher in cases than controls (0.72 ± 0.53 vs 0.51 ± 0.64 g-10/mL; p = 0.01). A nonparametric test on nontransformed data (median harmane = 5.21 g-10/mL in cases and 2.28 g-10/mL in controls) confirmed this difference (p = 0.005). The mean log blood concentration of harmine was 0.20 ± 0.48 g-10/mL in cases and 0,10 ± 0.65 g-10/mL in controls (p = 0.20). Log harmane concentrations were stratified based on the median value; 62% of cases vs 39% of controls had a high log harmane concentration (p = 0.001). Mean log harmane concentration was similar in the cases with (0.74 ± 0.58 g-10/mL) and without (0.71 ± 0.50 g-10/mL) an affected relative (p = 0.83). Conclusions: Blood concentrations of harmane were measured in ET cases compared with controls. Concentrations were elevated in cases with and without a family history of ET.

Original languageEnglish (US)
Pages (from-to)1940-1944
Number of pages5
JournalNeurology
Volume59
Issue number12
DOIs
StatePublished - Dec 24 2002
Externally publishedYes

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Essential Tremor
Carbolines
Alkaloids
Harmine
Food Chain
Tremor
harman
High Pressure Liquid Chromatography

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Louis, E. D., Zheng, W., Jurewicz, E. C., Watner, D., Chen, J., Factor-Litvak, P., & Parides, M. K. (2002). Elevation of blood Β-carboline alkaloids in essential tremor. Neurology, 59(12), 1940-1944. https://doi.org/10.1212/01.WNL.0000038385.60538.19

Elevation of blood Β-carboline alkaloids in essential tremor. / Louis, Elan D.; Zheng, W.; Jurewicz, E. C.; Watner, D.; Chen, J.; Factor-Litvak, P.; Parides, Michael K.

In: Neurology, Vol. 59, No. 12, 24.12.2002, p. 1940-1944.

Research output: Contribution to journalArticle

Louis, ED, Zheng, W, Jurewicz, EC, Watner, D, Chen, J, Factor-Litvak, P & Parides, MK 2002, 'Elevation of blood Β-carboline alkaloids in essential tremor', Neurology, vol. 59, no. 12, pp. 1940-1944. https://doi.org/10.1212/01.WNL.0000038385.60538.19
Louis ED, Zheng W, Jurewicz EC, Watner D, Chen J, Factor-Litvak P et al. Elevation of blood Β-carboline alkaloids in essential tremor. Neurology. 2002 Dec 24;59(12):1940-1944. https://doi.org/10.1212/01.WNL.0000038385.60538.19
Louis, Elan D. ; Zheng, W. ; Jurewicz, E. C. ; Watner, D. ; Chen, J. ; Factor-Litvak, P. ; Parides, Michael K. / Elevation of blood Β-carboline alkaloids in essential tremor. In: Neurology. 2002 ; Vol. 59, No. 12. pp. 1940-1944.
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AU - Factor-Litvak, P.

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