Elevated tumor necrosis factor-α in association with severe anemia in human immunodeficiency virus infection and mycobacterium avium intracellulare infection

Maadhava Ellaurie, Arye Rubinstein

Research output: Contribution to journalArticle

15 Scopus citations


Mycobacterium avium intracellulare (MAI) infection is a serious opportunistic infection that occurs in children with human immunodeficiency virus (HIV) infection. In MAI the hematologic system is profoundly affected. In the present study the hematologic manifestations of MAI in 37 HIV-infected infants and children were reviewed. Anemia was the predominant feature in all patients, with severe anemia (hemoglobin < 6 g/dL) occurring in 7 of 34 (21% patients. This was followed by leukopenia (79% monocytosis (82% thrombocytopenia (59% leukoerythroblastic reaction (68% and neutropenia (41% Serum tumor necrosis factor (TNF)-α was markedly elevated in all patients with MAI with an X ± SE of 702 ± 182 pg/mL. There was an association between elevated TNF-α and anemia in these patients.

Original languageEnglish (US)
Pages (from-to)221-230
Number of pages10
JournalPediatric Hematology and Oncology
Issue number3
Publication statusPublished - Jan 1 1995



  • AIDS
  • Anemia
  • HIV
  • Mycobacterium avium intracellulare (MAI)
  • Tumor necrosis factor (TNF)

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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