Elevated tricuspid regurgitant jet velocity in children and adolescents with sickle cell disease

Association with hemolysis and hemoglobin oxygen desaturation

Caterina P. Minniti, Craig Sable, Andrew Campbell, Sohail Rana, Gregory Ensing, Niti Dham, Onyinye Onyekwere, Mehdi Nouraie, Gregory J. Kato, Mark T. Gladwin, Oswaldo L. Castro, Victor R. Gordeuk

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

Background Elevation of echocardiography-determined tricuspid regurgitant jet velocity predicts high systolic pulmonary artery pressure and early mortality in adults with sickle cell disease. The definition, prevalence and clinical correlates of elevated jet velocity have not been established in pediatric patients. The present study tested the hypotheses that elevated jet velocity affects 10% of pediatric patients, is associated with both hemolysis and hypoxia, and has clinical correlates with acute chest syndrome, stroke, transfusion requirement and abnormal 6-minute walk test results. Desingn and Methods A prospective multicenter study of 310 patients aged 3-20 years old with sickle cell disease under basal conditions and 54 matched controls was conducted. A hemolytic index was generated by principal component analysis of the levels of lactate dehydrogenase, aspartate aminotransferase and bilirubin and reticulocyte count. Results Elevated jet velocity (defined as ≥2.60 m/sec based on the mean±2 SD in controls) occurred in 32 patients (11.0%) including one child of 3 years old. After adjustment for hemoglobin concentration, systolic blood pressure and left ventricular diastolic function, a 2 SD increase in the hemolytic index was associated with a 4.5-fold increase in the odds of elevated jet velocity (=0.009) and oxygen saturation ≤98% with a 3.2-fold increase (=0.028). Two or more episodes of acute chest syndrome had occurred in 28% of children with elevated jet velocity compared to in 13% of other children (=0.012), more than ten units of blood had been transfused in 39% versus 18% (=0.017) and stroke had occurred in 19% versus 11% (p=0.2). The distance walked in 6-minute walk tests did not differ significantly, but oxygen saturation declined during the tests in 68% of children with elevated jet velocity compared to in 32% of other children (=0.0002). Conclusions According to a pediatric-specific definition the prevalence of elevated jet velocity in this population of young patients with sickle cell disease was 11%. The study provides evidence for independent associations of elevated jet velocity with hemolysis and oxygen desaturation. Further investigations should address whether elevated jet velocity may indicate future complications and whether early intervention is beneficial.

Original languageEnglish (US)
Pages (from-to)340-347
Number of pages8
JournalHaematologica
Volume94
Issue number3
DOIs
StatePublished - Mar 2009
Externally publishedYes

Fingerprint

Sickle Cell Anemia
Hemolysis
Hemoglobins
Oxygen
Acute Chest Syndrome
Pediatrics
Stroke
Blood Pressure
Reticulocyte Count
Aspartate Aminotransferases
Principal Component Analysis
Left Ventricular Function
L-Lactate Dehydrogenase
Bilirubin
Pulmonary Artery
Multicenter Studies
Echocardiography
Prospective Studies
Pressure
Mortality

Keywords

  • Children
  • Hemolysis
  • Oxygen saturation
  • Pulmonary hypertension
  • Sickle cell disease
  • Tricuspid regurgitant jet velocity

ASJC Scopus subject areas

  • Hematology

Cite this

Elevated tricuspid regurgitant jet velocity in children and adolescents with sickle cell disease : Association with hemolysis and hemoglobin oxygen desaturation. / Minniti, Caterina P.; Sable, Craig; Campbell, Andrew; Rana, Sohail; Ensing, Gregory; Dham, Niti; Onyekwere, Onyinye; Nouraie, Mehdi; Kato, Gregory J.; Gladwin, Mark T.; Castro, Oswaldo L.; Gordeuk, Victor R.

In: Haematologica, Vol. 94, No. 3, 03.2009, p. 340-347.

Research output: Contribution to journalArticle

Minniti, CP, Sable, C, Campbell, A, Rana, S, Ensing, G, Dham, N, Onyekwere, O, Nouraie, M, Kato, GJ, Gladwin, MT, Castro, OL & Gordeuk, VR 2009, 'Elevated tricuspid regurgitant jet velocity in children and adolescents with sickle cell disease: Association with hemolysis and hemoglobin oxygen desaturation', Haematologica, vol. 94, no. 3, pp. 340-347. https://doi.org/10.3324/haematol.13812
Minniti, Caterina P. ; Sable, Craig ; Campbell, Andrew ; Rana, Sohail ; Ensing, Gregory ; Dham, Niti ; Onyekwere, Onyinye ; Nouraie, Mehdi ; Kato, Gregory J. ; Gladwin, Mark T. ; Castro, Oswaldo L. ; Gordeuk, Victor R. / Elevated tricuspid regurgitant jet velocity in children and adolescents with sickle cell disease : Association with hemolysis and hemoglobin oxygen desaturation. In: Haematologica. 2009 ; Vol. 94, No. 3. pp. 340-347.
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abstract = "Background Elevation of echocardiography-determined tricuspid regurgitant jet velocity predicts high systolic pulmonary artery pressure and early mortality in adults with sickle cell disease. The definition, prevalence and clinical correlates of elevated jet velocity have not been established in pediatric patients. The present study tested the hypotheses that elevated jet velocity affects 10{\%} of pediatric patients, is associated with both hemolysis and hypoxia, and has clinical correlates with acute chest syndrome, stroke, transfusion requirement and abnormal 6-minute walk test results. Desingn and Methods A prospective multicenter study of 310 patients aged 3-20 years old with sickle cell disease under basal conditions and 54 matched controls was conducted. A hemolytic index was generated by principal component analysis of the levels of lactate dehydrogenase, aspartate aminotransferase and bilirubin and reticulocyte count. Results Elevated jet velocity (defined as ≥2.60 m/sec based on the mean±2 SD in controls) occurred in 32 patients (11.0{\%}) including one child of 3 years old. After adjustment for hemoglobin concentration, systolic blood pressure and left ventricular diastolic function, a 2 SD increase in the hemolytic index was associated with a 4.5-fold increase in the odds of elevated jet velocity (=0.009) and oxygen saturation ≤98{\%} with a 3.2-fold increase (=0.028). Two or more episodes of acute chest syndrome had occurred in 28{\%} of children with elevated jet velocity compared to in 13{\%} of other children (=0.012), more than ten units of blood had been transfused in 39{\%} versus 18{\%} (=0.017) and stroke had occurred in 19{\%} versus 11{\%} (p=0.2). The distance walked in 6-minute walk tests did not differ significantly, but oxygen saturation declined during the tests in 68{\%} of children with elevated jet velocity compared to in 32{\%} of other children (=0.0002). Conclusions According to a pediatric-specific definition the prevalence of elevated jet velocity in this population of young patients with sickle cell disease was 11{\%}. The study provides evidence for independent associations of elevated jet velocity with hemolysis and oxygen desaturation. Further investigations should address whether elevated jet velocity may indicate future complications and whether early intervention is beneficial.",
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T1 - Elevated tricuspid regurgitant jet velocity in children and adolescents with sickle cell disease

T2 - Association with hemolysis and hemoglobin oxygen desaturation

AU - Minniti, Caterina P.

AU - Sable, Craig

AU - Campbell, Andrew

AU - Rana, Sohail

AU - Ensing, Gregory

AU - Dham, Niti

AU - Onyekwere, Onyinye

AU - Nouraie, Mehdi

AU - Kato, Gregory J.

AU - Gladwin, Mark T.

AU - Castro, Oswaldo L.

AU - Gordeuk, Victor R.

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N2 - Background Elevation of echocardiography-determined tricuspid regurgitant jet velocity predicts high systolic pulmonary artery pressure and early mortality in adults with sickle cell disease. The definition, prevalence and clinical correlates of elevated jet velocity have not been established in pediatric patients. The present study tested the hypotheses that elevated jet velocity affects 10% of pediatric patients, is associated with both hemolysis and hypoxia, and has clinical correlates with acute chest syndrome, stroke, transfusion requirement and abnormal 6-minute walk test results. Desingn and Methods A prospective multicenter study of 310 patients aged 3-20 years old with sickle cell disease under basal conditions and 54 matched controls was conducted. A hemolytic index was generated by principal component analysis of the levels of lactate dehydrogenase, aspartate aminotransferase and bilirubin and reticulocyte count. Results Elevated jet velocity (defined as ≥2.60 m/sec based on the mean±2 SD in controls) occurred in 32 patients (11.0%) including one child of 3 years old. After adjustment for hemoglobin concentration, systolic blood pressure and left ventricular diastolic function, a 2 SD increase in the hemolytic index was associated with a 4.5-fold increase in the odds of elevated jet velocity (=0.009) and oxygen saturation ≤98% with a 3.2-fold increase (=0.028). Two or more episodes of acute chest syndrome had occurred in 28% of children with elevated jet velocity compared to in 13% of other children (=0.012), more than ten units of blood had been transfused in 39% versus 18% (=0.017) and stroke had occurred in 19% versus 11% (p=0.2). The distance walked in 6-minute walk tests did not differ significantly, but oxygen saturation declined during the tests in 68% of children with elevated jet velocity compared to in 32% of other children (=0.0002). Conclusions According to a pediatric-specific definition the prevalence of elevated jet velocity in this population of young patients with sickle cell disease was 11%. The study provides evidence for independent associations of elevated jet velocity with hemolysis and oxygen desaturation. Further investigations should address whether elevated jet velocity may indicate future complications and whether early intervention is beneficial.

AB - Background Elevation of echocardiography-determined tricuspid regurgitant jet velocity predicts high systolic pulmonary artery pressure and early mortality in adults with sickle cell disease. The definition, prevalence and clinical correlates of elevated jet velocity have not been established in pediatric patients. The present study tested the hypotheses that elevated jet velocity affects 10% of pediatric patients, is associated with both hemolysis and hypoxia, and has clinical correlates with acute chest syndrome, stroke, transfusion requirement and abnormal 6-minute walk test results. Desingn and Methods A prospective multicenter study of 310 patients aged 3-20 years old with sickle cell disease under basal conditions and 54 matched controls was conducted. A hemolytic index was generated by principal component analysis of the levels of lactate dehydrogenase, aspartate aminotransferase and bilirubin and reticulocyte count. Results Elevated jet velocity (defined as ≥2.60 m/sec based on the mean±2 SD in controls) occurred in 32 patients (11.0%) including one child of 3 years old. After adjustment for hemoglobin concentration, systolic blood pressure and left ventricular diastolic function, a 2 SD increase in the hemolytic index was associated with a 4.5-fold increase in the odds of elevated jet velocity (=0.009) and oxygen saturation ≤98% with a 3.2-fold increase (=0.028). Two or more episodes of acute chest syndrome had occurred in 28% of children with elevated jet velocity compared to in 13% of other children (=0.012), more than ten units of blood had been transfused in 39% versus 18% (=0.017) and stroke had occurred in 19% versus 11% (p=0.2). The distance walked in 6-minute walk tests did not differ significantly, but oxygen saturation declined during the tests in 68% of children with elevated jet velocity compared to in 32% of other children (=0.0002). Conclusions According to a pediatric-specific definition the prevalence of elevated jet velocity in this population of young patients with sickle cell disease was 11%. The study provides evidence for independent associations of elevated jet velocity with hemolysis and oxygen desaturation. Further investigations should address whether elevated jet velocity may indicate future complications and whether early intervention is beneficial.

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KW - Oxygen saturation

KW - Pulmonary hypertension

KW - Sickle cell disease

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