Elevated serum homocysteine levels and increased risk of invasive cervical cancer in US women

S. J. Weinstein, R. G. Ziegler, J. Selhub, T. R. Fears, Howard Strickler, L. A. Brinton, R. F. Hamman, R. S. Levine, K. Mallin, P. D. Stolley

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Objectives: To explore the relationship between serum homocysteine, a sensitive biomarker for folate inadequacy and problems in one-carbon metabolism, and invasive cervical cancer. Methods: A large case-control study was conducted in five US areas with up to two community controls, obtained by random-digit dialing, individually matched to each case. Cervical cancer risk factors were assessed through at-home interview. Blood was drawn at least 6 months after completion of cancer treatment from 51% and 68% of interviewed cases and controls. Serum homocysteine was measured by high-performance liquid chromatography, and exposure to human papillomavirus (HPV) type 16, the most prevalent oncogenic type, was assessed using an enzyme-linked immunosorbent assay. Cases with advanced cancer and/or receiving chemotherapy were excluded, leaving 183 cases and 540 controls. Results: Invasive cervical cancer risk was substantially elevated for women in the upper three homocysteine quartiles (> 6.31 μmol/L); multivariate-adjusted odds ratios ranged from 2.4 to 3.2 (all 95% CIs excluded 1.0). A trend was apparent and significant (p = 0.01). When cases were compared with HPV-16 seropositive controls only, odds ratios were comparable. Conclusions: Serum homocysteine was strongly and significantly predictive of invasive cervical cancer risk. This association could reflect folate, B12 and/or B6 inadequacy, or genetic polymorphisms affecting one-carbon metabolism.

Original languageEnglish (US)
Pages (from-to)317-324
Number of pages8
JournalCancer Causes and Control
Volume12
Issue number4
DOIs
StatePublished - 2001

Fingerprint

Homocysteine
Uterine Cervical Neoplasms
Human papillomavirus 16
Serum
Folic Acid
Carbon
Odds Ratio
Genetic Polymorphisms
Case-Control Studies
Neoplasms
Biomarkers
Enzyme-Linked Immunosorbent Assay
High Pressure Liquid Chromatography
Interviews
Drug Therapy
Therapeutics

Keywords

  • Cervix neoplasms
  • Homocysteine
  • Nutrition

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

Cite this

Weinstein, S. J., Ziegler, R. G., Selhub, J., Fears, T. R., Strickler, H., Brinton, L. A., ... Stolley, P. D. (2001). Elevated serum homocysteine levels and increased risk of invasive cervical cancer in US women. Cancer Causes and Control, 12(4), 317-324. https://doi.org/10.1023/A:1011290103779

Elevated serum homocysteine levels and increased risk of invasive cervical cancer in US women. / Weinstein, S. J.; Ziegler, R. G.; Selhub, J.; Fears, T. R.; Strickler, Howard; Brinton, L. A.; Hamman, R. F.; Levine, R. S.; Mallin, K.; Stolley, P. D.

In: Cancer Causes and Control, Vol. 12, No. 4, 2001, p. 317-324.

Research output: Contribution to journalArticle

Weinstein, SJ, Ziegler, RG, Selhub, J, Fears, TR, Strickler, H, Brinton, LA, Hamman, RF, Levine, RS, Mallin, K & Stolley, PD 2001, 'Elevated serum homocysteine levels and increased risk of invasive cervical cancer in US women', Cancer Causes and Control, vol. 12, no. 4, pp. 317-324. https://doi.org/10.1023/A:1011290103779
Weinstein, S. J. ; Ziegler, R. G. ; Selhub, J. ; Fears, T. R. ; Strickler, Howard ; Brinton, L. A. ; Hamman, R. F. ; Levine, R. S. ; Mallin, K. ; Stolley, P. D. / Elevated serum homocysteine levels and increased risk of invasive cervical cancer in US women. In: Cancer Causes and Control. 2001 ; Vol. 12, No. 4. pp. 317-324.
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