Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people

Qibin Qi, Zhijie Yu, Xingwang Ye, Feng Zhao, Ping Huang, Frank B. Hu, Oscar H. Franco, Jing Wang, Huaixing Li, Yong Liu, Xu Lin

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

Context: High retinol-binding protein 4 (RBP4) is thought to be associated with insulin resistance in humans. However, evidence from large-scale populations about the relationship between RBP4 and metabolic diseases is scarce. Objective: We evaluated plasma RBP4 distribution and its association with metabolic syndrome (MetS) among middle-aged and older Chinese. Research Design and Methods: We evaluated plasma RBP4 in a cross-sectional sample of 3289 Chinese aged from 50 to 70 yr in Beijing and Shanghai by using an in-house developed and validated sandwich ELISA. MetS was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian-Americans. Results: RBP4 levels were higher in male and Beijing residents, compared with female and Shanghai participants (both P < 0.001). RBP4 levels were associated positively with body mass index, waist circumference, triglycerides, total and low-density lipoprotein cholesterol, blood pressure, fasting insulin, and homeostatic model assessment of insulin resistance and negatively with high-density lipoprotein cholesterol and adiponectin (all P < 0.001). In the highest RBP4 quartile, the MetS risk was significantly higher (odds ratio 2.58; 95% confidence interval 2.08-3.20) than in the lowest quartile after adjustment for potential confounders. This association remained strong (odds ratio 2.25; 95% confidence interval 1.72-2.94) after further controlling for C-reactive protein, adiponectin, homeostatic model assessment of insulin resistance, and body mass index. Conclusions: This first large-scale population study shows that elevated RBP4 levels are strongly and independently associated with MetS. Prospective studies are needed to establish the role of RBP4 in the development of MetS and related diseases.

Original languageEnglish (US)
Pages (from-to)4827-4834
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume92
Issue number12
DOIs
StatePublished - Dec 2007
Externally publishedYes

Fingerprint

Retinol-Binding Proteins
Plasma Retinol-Binding Proteins
Insulin
Insulin Resistance
Adiponectin
Body Mass Index
Odds Ratio
Confidence Intervals
Asian Americans
Metabolic Diseases
Blood pressure
Waist Circumference
C-Reactive Protein
LDL Cholesterol
HDL Cholesterol
Population
Fasting
Triglycerides
Research Design
Education

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people. / Qi, Qibin; Yu, Zhijie; Ye, Xingwang; Zhao, Feng; Huang, Ping; Hu, Frank B.; Franco, Oscar H.; Wang, Jing; Li, Huaixing; Liu, Yong; Lin, Xu.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 92, No. 12, 12.2007, p. 4827-4834.

Research output: Contribution to journalArticle

Qi, Q, Yu, Z, Ye, X, Zhao, F, Huang, P, Hu, FB, Franco, OH, Wang, J, Li, H, Liu, Y & Lin, X 2007, 'Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people', Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 12, pp. 4827-4834. https://doi.org/10.1210/jc.2007-1219
Qi, Qibin ; Yu, Zhijie ; Ye, Xingwang ; Zhao, Feng ; Huang, Ping ; Hu, Frank B. ; Franco, Oscar H. ; Wang, Jing ; Li, Huaixing ; Liu, Yong ; Lin, Xu. / Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people. In: Journal of Clinical Endocrinology and Metabolism. 2007 ; Vol. 92, No. 12. pp. 4827-4834.
@article{282c6cbae5884bbbb7293b628e0f9b4e,
title = "Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people",
abstract = "Context: High retinol-binding protein 4 (RBP4) is thought to be associated with insulin resistance in humans. However, evidence from large-scale populations about the relationship between RBP4 and metabolic diseases is scarce. Objective: We evaluated plasma RBP4 distribution and its association with metabolic syndrome (MetS) among middle-aged and older Chinese. Research Design and Methods: We evaluated plasma RBP4 in a cross-sectional sample of 3289 Chinese aged from 50 to 70 yr in Beijing and Shanghai by using an in-house developed and validated sandwich ELISA. MetS was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian-Americans. Results: RBP4 levels were higher in male and Beijing residents, compared with female and Shanghai participants (both P < 0.001). RBP4 levels were associated positively with body mass index, waist circumference, triglycerides, total and low-density lipoprotein cholesterol, blood pressure, fasting insulin, and homeostatic model assessment of insulin resistance and negatively with high-density lipoprotein cholesterol and adiponectin (all P < 0.001). In the highest RBP4 quartile, the MetS risk was significantly higher (odds ratio 2.58; 95{\%} confidence interval 2.08-3.20) than in the lowest quartile after adjustment for potential confounders. This association remained strong (odds ratio 2.25; 95{\%} confidence interval 1.72-2.94) after further controlling for C-reactive protein, adiponectin, homeostatic model assessment of insulin resistance, and body mass index. Conclusions: This first large-scale population study shows that elevated RBP4 levels are strongly and independently associated with MetS. Prospective studies are needed to establish the role of RBP4 in the development of MetS and related diseases.",
author = "Qibin Qi and Zhijie Yu and Xingwang Ye and Feng Zhao and Ping Huang and Hu, {Frank B.} and Franco, {Oscar H.} and Jing Wang and Huaixing Li and Yong Liu and Xu Lin",
year = "2007",
month = "12",
doi = "10.1210/jc.2007-1219",
language = "English (US)",
volume = "92",
pages = "4827--4834",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "12",

}

TY - JOUR

T1 - Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people

AU - Qi, Qibin

AU - Yu, Zhijie

AU - Ye, Xingwang

AU - Zhao, Feng

AU - Huang, Ping

AU - Hu, Frank B.

AU - Franco, Oscar H.

AU - Wang, Jing

AU - Li, Huaixing

AU - Liu, Yong

AU - Lin, Xu

PY - 2007/12

Y1 - 2007/12

N2 - Context: High retinol-binding protein 4 (RBP4) is thought to be associated with insulin resistance in humans. However, evidence from large-scale populations about the relationship between RBP4 and metabolic diseases is scarce. Objective: We evaluated plasma RBP4 distribution and its association with metabolic syndrome (MetS) among middle-aged and older Chinese. Research Design and Methods: We evaluated plasma RBP4 in a cross-sectional sample of 3289 Chinese aged from 50 to 70 yr in Beijing and Shanghai by using an in-house developed and validated sandwich ELISA. MetS was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian-Americans. Results: RBP4 levels were higher in male and Beijing residents, compared with female and Shanghai participants (both P < 0.001). RBP4 levels were associated positively with body mass index, waist circumference, triglycerides, total and low-density lipoprotein cholesterol, blood pressure, fasting insulin, and homeostatic model assessment of insulin resistance and negatively with high-density lipoprotein cholesterol and adiponectin (all P < 0.001). In the highest RBP4 quartile, the MetS risk was significantly higher (odds ratio 2.58; 95% confidence interval 2.08-3.20) than in the lowest quartile after adjustment for potential confounders. This association remained strong (odds ratio 2.25; 95% confidence interval 1.72-2.94) after further controlling for C-reactive protein, adiponectin, homeostatic model assessment of insulin resistance, and body mass index. Conclusions: This first large-scale population study shows that elevated RBP4 levels are strongly and independently associated with MetS. Prospective studies are needed to establish the role of RBP4 in the development of MetS and related diseases.

AB - Context: High retinol-binding protein 4 (RBP4) is thought to be associated with insulin resistance in humans. However, evidence from large-scale populations about the relationship between RBP4 and metabolic diseases is scarce. Objective: We evaluated plasma RBP4 distribution and its association with metabolic syndrome (MetS) among middle-aged and older Chinese. Research Design and Methods: We evaluated plasma RBP4 in a cross-sectional sample of 3289 Chinese aged from 50 to 70 yr in Beijing and Shanghai by using an in-house developed and validated sandwich ELISA. MetS was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian-Americans. Results: RBP4 levels were higher in male and Beijing residents, compared with female and Shanghai participants (both P < 0.001). RBP4 levels were associated positively with body mass index, waist circumference, triglycerides, total and low-density lipoprotein cholesterol, blood pressure, fasting insulin, and homeostatic model assessment of insulin resistance and negatively with high-density lipoprotein cholesterol and adiponectin (all P < 0.001). In the highest RBP4 quartile, the MetS risk was significantly higher (odds ratio 2.58; 95% confidence interval 2.08-3.20) than in the lowest quartile after adjustment for potential confounders. This association remained strong (odds ratio 2.25; 95% confidence interval 1.72-2.94) after further controlling for C-reactive protein, adiponectin, homeostatic model assessment of insulin resistance, and body mass index. Conclusions: This first large-scale population study shows that elevated RBP4 levels are strongly and independently associated with MetS. Prospective studies are needed to establish the role of RBP4 in the development of MetS and related diseases.

UR - http://www.scopus.com/inward/record.url?scp=36849008667&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36849008667&partnerID=8YFLogxK

U2 - 10.1210/jc.2007-1219

DO - 10.1210/jc.2007-1219

M3 - Article

VL - 92

SP - 4827

EP - 4834

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 12

ER -