Abstract
Advanced glycation endproducts (AGEs), which accumulate in diabetic vasculature, result in enhanced expression of endothelial cell-associated vascular cell adhesion molecule-1 (VCAM-1) as well release of a soluble form of VCAM-1 (sVCAM-1) into culture supernatants. We hypothesized that sVCAM-1 in diabetic plasma might reflect early vascular perturbation in diabetic vasculopathy. Diabetic patients with microalbuminuria, a group with a high incidence of vascular complications, had increased plasma levels of sVCAM-1, ~1.5-fold greater than diabetic patients without microalbuminuria; P < 0.05. sVCAM-1 may be an indicator of ongoing cellular dysfunction in diabetes, as well as a dynamic surrogate marker for the effectiveness of therapeutic interventions.
Original language | English (US) |
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Pages (from-to) | 747-750 |
Number of pages | 4 |
Journal | British Journal of Haematology |
Volume | 92 |
Issue number | 3 |
DOIs | |
State | Published - 1996 |
Externally published | Yes |
Keywords
- Adhesion molecule
- Diabetes
- Glycation
- Microalbuminuria
- Vasculopathy
ASJC Scopus subject areas
- Hematology