Elevated plasma levels of vascular cell adhesion molecule-1 (VCAM-1) in diabetic patients with microalbuminuria: A marker of vascular dysfunction and progressive vascular disease

Ann Marie Schmidt, Jill Crandall, Osamu Hori, Rong Cao, Edward Lakatta

Research output: Contribution to journalArticlepeer-review

102 Scopus citations

Abstract

Advanced glycation endproducts (AGEs), which accumulate in diabetic vasculature, result in enhanced expression of endothelial cell-associated vascular cell adhesion molecule-1 (VCAM-1) as well release of a soluble form of VCAM-1 (sVCAM-1) into culture supernatants. We hypothesized that sVCAM-1 in diabetic plasma might reflect early vascular perturbation in diabetic vasculopathy. Diabetic patients with microalbuminuria, a group with a high incidence of vascular complications, had increased plasma levels of sVCAM-1, ~1.5-fold greater than diabetic patients without microalbuminuria; P < 0.05. sVCAM-1 may be an indicator of ongoing cellular dysfunction in diabetes, as well as a dynamic surrogate marker for the effectiveness of therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)747-750
Number of pages4
JournalBritish Journal of Haematology
Volume92
Issue number3
DOIs
StatePublished - 1996
Externally publishedYes

Keywords

  • Adhesion molecule
  • Diabetes
  • Glycation
  • Microalbuminuria
  • Vasculopathy

ASJC Scopus subject areas

  • Hematology

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