Elevated plasma levels of chemerin in newly diagnosed type 2 diabetes mellitus with hypertension

Yang Mengliu, Yang Gangyi, Dong Jing, Liu Ying, Zong Haihong, Liu Hua, Guenther Boden, Li Ling

Research output: Contribution to journalArticle

Abstract

Chemerin is a recently discovered metabolic regulator hormone. The pathophysiologic role of this hormone in humans remains unknown. In this study, we have compared plasma chemerin levels in patients with type 2 diabetes mellitus with or without hypertension and in control subjects. We also assessed the association of plasma chemerin with body composition and metabolic parameters in these subjects. Plasma chemerin levels were found to be markedly increased in patients with type 2 diabetes mellitus with hypertension as compared with patients with type 2 diabetes mellitus and normal controls (P < 0.01). Multiple regression analysis showed that waist circumference, diastolic blood pressure, 2-hour plasma insulin after glucose overload, and HbA1c were independently related factors influencing plasma chemerin levels. The present work indicates the potential link of chemerin with the pathogenesis of insulin resistance, obesity, and metabolic syndrome.

Original languageEnglish (US)
Pages (from-to)883-886
Number of pages4
JournalJournal of Investigative Medicine
Volume58
Issue number7
DOIs
Publication statusPublished - Oct 2010

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Keywords

  • Body composition
  • Chemerin
  • Hypertension
  • Metabolic parameters
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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