Elevated body mass index is associated with lower serum anti-mullerian hormone levels in infertile women with diminished ovarian reserve but not with normal ovarian reserve

Erkan Buyuk, David B. Seifer, Edward Illions, Richard V. Grazi, Harry J. Lieman

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Objective: To investigate the association between elevated body mass index (BMI) and ovarian reserve. Design: Cross-sectional study. Setting: Academic institutions. Patient(s): Two hundred ninety women with infertility. Diminished ovarian reserve (DOR) was defined as day 3 FSH >10 IU/L. Intervention(s): None. Main Outcome Measure(s): Random serum antimullerian hormone (AMH) levels and number of oocytes retrieved during assisted reproductive technology cycle. Result(s): Increasing BMI was associated with lower random serum AMH levels in infertile women with DOR but not in women with normal ovarian reserve (NOR). Among women with DOR, mean random serum AMH levels were 33% lower in overweight and obese women compared with women with normal weight. The same association was not true for women with NOR. Out of 290 women evaluated for infertility, 109 women underwent a controlled ovarian hyperstimulation (COH)-IVF cycle. Women with elevated BMI and DOR had lower number of oocytes retrieved compared with women with normal BMI and DOR (6.4 ± 4.3 vs. 9.4 ± 6), an association that was not observed among women with NOR. Conclusion(s): Overweight and obese women with DOR as defined by high day 3 serum FSH levels have lower serum AMH levels and number of oocytes retrieved compared with nonobese women with DOR.

Original languageEnglish (US)
Pages (from-to)2364-2368
Number of pages5
JournalFertility and Sterility
Volume95
Issue number7
DOIs
StatePublished - Jun 2011

Fingerprint

Anti-Mullerian Hormone
Body Mass Index
Serum
Oocytes
Ovarian Reserve
Infertility
Assisted Reproductive Techniques

Keywords

  • antimullerian hormone
  • Body mass index
  • obesity
  • ovarian reserve

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Elevated body mass index is associated with lower serum anti-mullerian hormone levels in infertile women with diminished ovarian reserve but not with normal ovarian reserve. / Buyuk, Erkan; Seifer, David B.; Illions, Edward; Grazi, Richard V.; Lieman, Harry J.

In: Fertility and Sterility, Vol. 95, No. 7, 06.2011, p. 2364-2368.

Research output: Contribution to journalArticle

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