Elevated basal intestinal mucosal cytokine levels in asymptomatic first-degree relatives of patients with Crohn's disease

A. V.K. Indaram, Sayan Nandi, S. Weissman, S. Lam, B. Bailey, M. Blumstein, R. Greenberg, S. Bank

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Aim: To determine levels of cytokines in colonic mucosa of asymptomatic first degree relatives of Crohn's disease patients. Methods: Cytokines (Interleukin (IL) 1-Beta, IL-2, IL-6 and IL-8) were measured using ELISA in biopsy samples of normal looking colonic mucosa of first degree relatives of Crohn's disease patients (n = 9) and from normal controls (n = 10) with no family history of Crohn's disease. Results: Asymptomatic first degree relatives of patients with Crohn's disease had significantly higher levels of basal intestinal mucosal cytokines (IL-2, IL-6 and IL-8) than normal controls. Whether these increased cytokine levels serve as phenotypic markers for a genetic predisposition to developing Crohn's disease later on, or whether they indicate early (pre-clinical) damage has yet to be further defined. Conclusion: Asymptomatic first degree relatives of Crohn's disease patients have higher levels of cytokines in their normal-looking intestinal mucosa compared to normal controls. This supports the hypothesis that increased cytokines may be a cause or an early event in the inflammatory cascade of Crohn's disease and are not merely a result of the inflammatory process.

Original languageEnglish (US)
Pages (from-to)49-52
Number of pages4
JournalWorld Journal of Gastroenterology
Volume6
Issue number1
StatePublished - Feb 1 2000

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Crohn Disease
Cytokines
Interleukin-8
Interleukin-2
Interleukin-6
Mucous Membrane
Intestinal Mucosa
Genetic Predisposition to Disease
Interleukin-1beta
Enzyme-Linked Immunosorbent Assay
Biopsy

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Elevated basal intestinal mucosal cytokine levels in asymptomatic first-degree relatives of patients with Crohn's disease. / Indaram, A. V.K.; Nandi, Sayan; Weissman, S.; Lam, S.; Bailey, B.; Blumstein, M.; Greenberg, R.; Bank, S.

In: World Journal of Gastroenterology, Vol. 6, No. 1, 01.02.2000, p. 49-52.

Research output: Contribution to journalArticle

Indaram, AVK, Nandi, S, Weissman, S, Lam, S, Bailey, B, Blumstein, M, Greenberg, R & Bank, S 2000, 'Elevated basal intestinal mucosal cytokine levels in asymptomatic first-degree relatives of patients with Crohn's disease', World Journal of Gastroenterology, vol. 6, no. 1, pp. 49-52.
Indaram, A. V.K. ; Nandi, Sayan ; Weissman, S. ; Lam, S. ; Bailey, B. ; Blumstein, M. ; Greenberg, R. ; Bank, S. / Elevated basal intestinal mucosal cytokine levels in asymptomatic first-degree relatives of patients with Crohn's disease. In: World Journal of Gastroenterology. 2000 ; Vol. 6, No. 1. pp. 49-52.
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AU - Nandi, Sayan

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AU - Lam, S.

AU - Bailey, B.

AU - Blumstein, M.

AU - Greenberg, R.

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