Electrophysiology of the normal-to-hypoxic transition zone

F. Bukauskas

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The 'normal-to-hypoxic' transition zone was modeled after the chamber technique for perpendicular and parallel orientation with respect to the direction of fiber axis. The evidence obtained from the recording of the transmembrane action potentials suggests the presence of a preservation phenomenon in the hypoxic area, based on the utilization of energy stores of the normoxic area. The preservation phenomenon is enhanced with improvement of the intercellular communication. Better intercellular coupling in longitudinal than in transverse fiber direction results in the anisotropic properties of the preservation phenomenon. The preservation phenomenon provides a basis for the existence of critical size of the viable hypoxic area compared to the size of the transitional zone. The crucial role of electrotonic coupling was demonstrated, as well as the possible contribution to the preservation phenomenon mechanism of the cell-to-cell diffusion of metabolites.

Original languageEnglish (US)
Pages (from-to)321-329
Number of pages9
JournalCirculation research
Volume51
Issue number3
DOIs
Publication statusPublished - Jan 1 1982

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ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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