Electrophysiological remodeling in heart failure

Fadi G. Akar, Gordon F. Tomaselli

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Ion channel remodeling in heart failure modulates key cellular electrophysiological properties, predisposing to arrhythmias and sudden death. Heart failure induced ion channel dysfunction prolongs the action potential, increases spatio-temporal gradients of repolarization, promotes arrhythmogenic triggers and results in conduction abnormalities. Understanding fundamental ionic mechanisms of normal and abnormal electrogenesis is a key requirement for the development of effective and safe therapies. Elucidating the underlying molecular mechanisms and functional consequences of ion channel remodeling at the cellular and organ levels presents a unique opportunity for the development of novel pharmacological, device, gene, and cell based approaches for the treatment of arrhythmias in heart failure.

Original languageEnglish (US)
Title of host publicationBasic Foundations and Primary Electrical Diseases
PublisherSpringer-Verlag London Ltd
Pages369-386
Number of pages18
Volume1
ISBN (Electronic)9781447148814
ISBN (Print)1447148800, 9781447148807
DOIs
Publication statusPublished - Mar 1 2013
Externally publishedYes

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Keywords

  • Arrhythmias
  • Cardiac resynchronization therapy
  • Conduction
  • Heart failure
  • Ion channels
  • Repolarization

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Akar, F. G., & Tomaselli, G. F. (2013). Electrophysiological remodeling in heart failure. In Basic Foundations and Primary Electrical Diseases (Vol. 1, pp. 369-386). Springer-Verlag London Ltd. https://doi.org/10.1007/978-1-4471-4881-4_22