Electrophysiologic properties of nitroprusside in man

L. Gould, C. V R Reddy, Soo G. Kim, K. C. Oh

Research output: Contribution to journalArticle

Abstract

The effects of nitroprusside on His bundle electrograms, when given intravenously for 10 minutes, were studied in 14 patients with heart disease. Recordings were made at varied heart rates using atrial and ventricular pacing. Nitroprusside significantly reduced the AH interval, but it had no effect on the HV interval. Functional and effective refractory periods were measured by the extrastimulus technique. The functional refractory period of the AV node as well as the effective refractory period of the ventriculoatrial conduction system significantly decreased after nitroprusside infusion. This improvement in conduction can probably be explained by the systemic hypotension produced by nitroprusside, which reflexly will increase sympathetic drive to the heart and decrease vagal tone.

Original languageEnglish (US)
Pages (from-to)841-849
Number of pages9
JournalAngiology
Volume30
Issue number12
StatePublished - 1979
Externally publishedYes

Fingerprint

Nitroprusside
Cardiac Electrophysiologic Techniques
Atrioventricular Node
Hypotension
Heart Diseases
Heart Rate

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Gould, L., Reddy, C. V. R., Kim, S. G., & Oh, K. C. (1979). Electrophysiologic properties of nitroprusside in man. Angiology, 30(12), 841-849.

Electrophysiologic properties of nitroprusside in man. / Gould, L.; Reddy, C. V R; Kim, Soo G.; Oh, K. C.

In: Angiology, Vol. 30, No. 12, 1979, p. 841-849.

Research output: Contribution to journalArticle

Gould, L, Reddy, CVR, Kim, SG & Oh, KC 1979, 'Electrophysiologic properties of nitroprusside in man', Angiology, vol. 30, no. 12, pp. 841-849.
Gould L, Reddy CVR, Kim SG, Oh KC. Electrophysiologic properties of nitroprusside in man. Angiology. 1979;30(12):841-849.
Gould, L. ; Reddy, C. V R ; Kim, Soo G. ; Oh, K. C. / Electrophysiologic properties of nitroprusside in man. In: Angiology. 1979 ; Vol. 30, No. 12. pp. 841-849.
@article{4a57fa2f65e6411c8652e6e97644f614,
title = "Electrophysiologic properties of nitroprusside in man",
abstract = "The effects of nitroprusside on His bundle electrograms, when given intravenously for 10 minutes, were studied in 14 patients with heart disease. Recordings were made at varied heart rates using atrial and ventricular pacing. Nitroprusside significantly reduced the AH interval, but it had no effect on the HV interval. Functional and effective refractory periods were measured by the extrastimulus technique. The functional refractory period of the AV node as well as the effective refractory period of the ventriculoatrial conduction system significantly decreased after nitroprusside infusion. This improvement in conduction can probably be explained by the systemic hypotension produced by nitroprusside, which reflexly will increase sympathetic drive to the heart and decrease vagal tone.",
author = "L. Gould and Reddy, {C. V R} and Kim, {Soo G.} and Oh, {K. C.}",
year = "1979",
language = "English (US)",
volume = "30",
pages = "841--849",
journal = "Angiology",
issn = "0003-3197",
publisher = "SAGE Publications Inc.",
number = "12",

}

TY - JOUR

T1 - Electrophysiologic properties of nitroprusside in man

AU - Gould, L.

AU - Reddy, C. V R

AU - Kim, Soo G.

AU - Oh, K. C.

PY - 1979

Y1 - 1979

N2 - The effects of nitroprusside on His bundle electrograms, when given intravenously for 10 minutes, were studied in 14 patients with heart disease. Recordings were made at varied heart rates using atrial and ventricular pacing. Nitroprusside significantly reduced the AH interval, but it had no effect on the HV interval. Functional and effective refractory periods were measured by the extrastimulus technique. The functional refractory period of the AV node as well as the effective refractory period of the ventriculoatrial conduction system significantly decreased after nitroprusside infusion. This improvement in conduction can probably be explained by the systemic hypotension produced by nitroprusside, which reflexly will increase sympathetic drive to the heart and decrease vagal tone.

AB - The effects of nitroprusside on His bundle electrograms, when given intravenously for 10 minutes, were studied in 14 patients with heart disease. Recordings were made at varied heart rates using atrial and ventricular pacing. Nitroprusside significantly reduced the AH interval, but it had no effect on the HV interval. Functional and effective refractory periods were measured by the extrastimulus technique. The functional refractory period of the AV node as well as the effective refractory period of the ventriculoatrial conduction system significantly decreased after nitroprusside infusion. This improvement in conduction can probably be explained by the systemic hypotension produced by nitroprusside, which reflexly will increase sympathetic drive to the heart and decrease vagal tone.

UR - http://www.scopus.com/inward/record.url?scp=0018573684&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018573684&partnerID=8YFLogxK

M3 - Article

C2 - 533014

AN - SCOPUS:0018573684

VL - 30

SP - 841

EP - 849

JO - Angiology

JF - Angiology

SN - 0003-3197

IS - 12

ER -