2-Ethoxyethaneseleninic acid reacts with electron-rich aromatic substrates to deliver, by way of the selenoxides, the (2-ethoxyethyl)seleno ethers, which can in turn be transformed into a diverse set of aryl-selenylated products. Among these, a family of 5-uridinyl derivatives shows submicromolar inhibition of human and malarial orotate phosphoribosyltransferase.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Jul 2 2010|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry