Electrophilic aromatic selenylation

New OPRT inhibitors

Mohannad Abdo, Yong Zhang, Vern L. Schramm, Spencer Knapp

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

2-Ethoxyethaneseleninic acid reacts with electron-rich aromatic substrates to deliver, by way of the selenoxides, the (2-ethoxyethyl)seleno ethers, which can in turn be transformed into a diverse set of aryl-selenylated products. Among these, a family of 5-uridinyl derivatives shows submicromolar inhibition of human and malarial orotate phosphoribosyltransferase.

Original languageEnglish (US)
Pages (from-to)2982-2985
Number of pages4
JournalOrganic Letters
Volume12
Issue number13
DOIs
StatePublished - Jul 2 2010

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Orotate Phosphoribosyltransferase
Ethers
inhibitors
ethers
Electrons
Derivatives
acids
Acids
Substrates
products
electrons

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Electrophilic aromatic selenylation : New OPRT inhibitors. / Abdo, Mohannad; Zhang, Yong; Schramm, Vern L.; Knapp, Spencer.

In: Organic Letters, Vol. 12, No. 13, 02.07.2010, p. 2982-2985.

Research output: Contribution to journalArticle

Abdo, Mohannad ; Zhang, Yong ; Schramm, Vern L. ; Knapp, Spencer. / Electrophilic aromatic selenylation : New OPRT inhibitors. In: Organic Letters. 2010 ; Vol. 12, No. 13. pp. 2982-2985.
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