Electronmicroscopic observation of amyloid deposits in the vascular walls of the choroid plexus in systemic amyloidosis

Imaharu Nakano, Asao Hirano, Masanori Tomonaga

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This report concerns an ultrastructural study of the vessels of the choroid plexus in 3 cases of systemic amyloidosis, sections of formalin-fixed brains being used. Small-sized arteries and arterioles were mainly affected by deposition of amyloid fibrils. In the arterioles, the amyloid fibrils were often so densely accumulated that they separated individual smooth muscle cells of the media and reached the subendothelial region. The basal surface of the endothelium of such vessels showed frequent invaginations filled with amyloid tufts; some of the tufts displaced the thin cytoplasm of the endothelial cells toward the lumen. Occasionally, tufts of amyloid fibrils were found to be exposed to and to float in the vascular lumen. These observations were made only in severely amyloid-laden vessels. Among the several possibilities regarding the tuft-endothelial relationship, the transendothelial transport of amyloid tufts is most likely, but the possibility of intraendothelial processing of amyloid precursor proteins and their secretion to form fibrils extracellularly cannot be excluded.

Original languageEnglish (US)
Pages (from-to)48-54
Number of pages7
JournalJournal of the Neurological Sciences
Volume108
Issue number1
DOIs
StatePublished - 1992

Fingerprint

Choroid Plexus
Amyloid Plaques
Amyloidosis
Amyloid
Blood Vessels
Observation
Arterioles
Amyloid beta-Protein Precursor
Formaldehyde
Smooth Muscle Myocytes
Endothelium
Cytoplasm
Endothelial Cells
Arteries
Brain

Keywords

  • Amyloid
  • Choroid plexus
  • Endothelial cell
  • Human
  • Systemic amyloidosis
  • Ultrastructure
  • Vessel

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

Cite this

Electronmicroscopic observation of amyloid deposits in the vascular walls of the choroid plexus in systemic amyloidosis. / Nakano, Imaharu; Hirano, Asao; Tomonaga, Masanori.

In: Journal of the Neurological Sciences, Vol. 108, No. 1, 1992, p. 48-54.

Research output: Contribution to journalArticle

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