Electron microscopic observations of peripheral myelin in a central nervous system lesion

Asao Hirano, H. M. Zimmerman, Seymour Levine

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

After cyanide intoxication and after triethyltin implantation in the brain, cystic spaces were found in the forebrains, of two rats. Within these spaces, many examples of remyelinating axons were observed. Most of them displayed typical mature or developing "central type" myelin sheaths. Some, however, showed all the morphological features characteristic of mature or developing peripheral myelin. In both rats, the cavities of the cysts were open to the overlying subarachnoid spaces due to partial disruption of the subpial astrocytic layer. It was concluded that the myelin-forming cells responsible for the formation of the "peripheral type" myelin within the cyst were probably Schwann cells derived from peripheral nervous elements accompanying some subarachnoid blood vessels. It could not be determined whether the axons within the "peripheral type" sheaths were part of the central or peripheral nervous systems. These data might be relevant to the origin of central neurinomas.

Original languageEnglish (US)
Pages (from-to)348-365
Number of pages18
JournalActa Neuropathologica
Volume12
Issue number4
DOIs
StatePublished - Dec 1969

Fingerprint

Myelin Sheath
Central Nervous System
Electrons
Axons
Cysts
Subarachnoid Space
Schwann Cells
Neurilemmoma
Peripheral Nervous System
Cyanides
Prosencephalon
Blood Vessels
Brain

Keywords

  • Central-Type Myelin
  • Myelin-forming Cell
  • Peripheral-Type Myelin
  • Remyelination
  • Schwann Cell

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Electron microscopic observations of peripheral myelin in a central nervous system lesion. / Hirano, Asao; Zimmerman, H. M.; Levine, Seymour.

In: Acta Neuropathologica, Vol. 12, No. 4, 12.1969, p. 348-365.

Research output: Contribution to journalArticle

Hirano, Asao ; Zimmerman, H. M. ; Levine, Seymour. / Electron microscopic observations of peripheral myelin in a central nervous system lesion. In: Acta Neuropathologica. 1969 ; Vol. 12, No. 4. pp. 348-365.
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