Electrolytic reduction of carrier-free 188Re

Ekaterina Dadachova, Suzanne V. Smith, Saed Mirzadeh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Electrolytic reduction of 188Re7+ as an alternative to reduction with SnCl2 for protein labeling has been investigated. The electrolysis cell consisted of an "H" type cell with a tungsten cathode and a platinum anode, and 7 M HCl as the supporting electrolyte. Reduction of 188ReO4- was conducted at 25-35 V (I = 0.05-0.5 A, current density on cathode 4 × 10-3-4 × 10-2 A·cm-2) for 15 min. Ascending paper chromatography on Whatman DE81 paper in 7 M HCl at 4°C confirmed that 75-77% of 188Re was reduced to the + 5 oxidation state. Subsequent to evaporation of 7 M HCl under nitrogen, it was shown that the reduced 188ReS+ as complexed with DMSA (meso-1,2-dimercaptosuccinic acid) or citrate at pH = 4.5 was stable with regard to reoxidation for up to 40 min.

Original languageEnglish (US)
Pages (from-to)289-292
Number of pages4
JournalApplied Radiation and Isotopes
Volume47
Issue number3
DOIs
StatePublished - Mar 1996
Externally publishedYes

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paper chromatography
cathodes
citrates
electrolysis
cells
marking
tungsten
platinum
anodes
evaporation
electrolytes
current density
proteins
nitrogen
oxidation
acids

ASJC Scopus subject areas

  • Radiation

Cite this

Electrolytic reduction of carrier-free 188Re. / Dadachova, Ekaterina; Smith, Suzanne V.; Mirzadeh, Saed.

In: Applied Radiation and Isotopes, Vol. 47, No. 3, 03.1996, p. 289-292.

Research output: Contribution to journalArticle

Dadachova, E, Smith, SV & Mirzadeh, S 1996, 'Electrolytic reduction of carrier-free 188Re', Applied Radiation and Isotopes, vol. 47, no. 3, pp. 289-292. https://doi.org/10.1016/0969-8043(95)00301-0
Dadachova, Ekaterina ; Smith, Suzanne V. ; Mirzadeh, Saed. / Electrolytic reduction of carrier-free 188Re. In: Applied Radiation and Isotopes. 1996 ; Vol. 47, No. 3. pp. 289-292.
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