Electrocardiographic QT interval and mortality: A meta-analysis

Yiyi Zhang, Wendy S. Post, Elena Blasco-Colmenares, Darshan Dalal, Gordon F. Tomaselli, Eliseo Guallara

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Abstract

Background: Extremely abnormal prolongation of the electrocardiographic QT interval is associated with malignant ventricular arrhythmias and sudden cardiac death. However, the implications of variations in QT-interval length within normal limits for mortality in the general population are still unclear. Methods: We performed a meta-analysis to investigate the relation of QT interval with mortality endpoints. Inverse-variance weighted random-effects models were used to summarize the relative risks across studies. Twenty-three observational studies were included. Results: The pooled relative risk estimates comparing the highest with the lowest categories of QT-interval length were 1.35 (95% confidence interval = 1.24-1.46) for total mortality, 1.51 (1.29-1.78) for cardiovascular mortality, 1.71 (1.36-2.15) for coronary heart disease mortality, and 1.44 (1.01-2.04) for sudden cardiac death. A 50 milliseconds increase in QT interval was associated with a relative risk of 1.20 (1.15-1.26) for total mortality, 1.29 (1.15-1.46) for cardiovascular mortality, 1.49 (1.25-1.76) for coronary heart disease mortality, and 1.24 (0.97-1.60) for sudden cardiac death. Conclusions: We found consistent associations between prolonged QT interval and increased risk of total, cardiovascular, coronary, and sudden cardiac death. QT-interval length is a determinant of mortality in the general population.

Original languageEnglish (US)
Pages (from-to)660-670
Number of pages11
JournalEpidemiology
Volume22
Issue number5
DOIs
StatePublished - Sep 1 2011
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology

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    Zhang, Y., Post, W. S., Blasco-Colmenares, E., Dalal, D., Tomaselli, G. F., & Guallara, E. (2011). Electrocardiographic QT interval and mortality: A meta-analysis. Epidemiology, 22(5), 660-670. https://doi.org/10.1097/EDE.0b013e318225768b