Electrical and structural remodeling of the failing ventricle

Antonis A. Armoundas; Richard Wu; George Juang; Eduardo Marbán; Gordon F. Tomaselli

doi:10.1016/S0163-7258(01)00171-1

Electrical and structural remodeling of the failing ventricle

Antonis A. Armoundas, Richard Wu, George Juang, Eduardo Marbán, Gordon F. Tomaselli

Research output: Contribution to journal › Review article › peer-review

85 Scopus citations

Abstract

Heart failure (HF) is a complex disease that presents a major public health challenge to Western society. The prevalence of HF increases with age in the elderly population, and the societal disease burden will increase with prolongation of life expectancy. HF is initially characterized by an adaptive increase of neurohumoral activation to compensate for reduction of cardiac output. This leads to a combination of neurohumoral activation and mechanical stress in the failing heart that trigger a cascade of maladaptive electrical and structural events that impair both the systolic and diastolic function of the heart.

Original language	English (US)
Pages (from-to)	213-230
Number of pages	18
Journal	Pharmacology and Therapeutics
Volume	92
Issue number	2-3
DOIs	https://doi.org/10.1016/S0163-7258(01)00171-1
State	Published - 2001
Externally published	Yes

Keywords

Arrhythmias
Heart failure
Ionic
Molecular
Remodeling

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0163-7258(01)00171-1

Cite this

@article{ed0efb63323c4d899acf6d29bf735bdf,

title = "Electrical and structural remodeling of the failing ventricle",

abstract = "Heart failure (HF) is a complex disease that presents a major public health challenge to Western society. The prevalence of HF increases with age in the elderly population, and the societal disease burden will increase with prolongation of life expectancy. HF is initially characterized by an adaptive increase of neurohumoral activation to compensate for reduction of cardiac output. This leads to a combination of neurohumoral activation and mechanical stress in the failing heart that trigger a cascade of maladaptive electrical and structural events that impair both the systolic and diastolic function of the heart.",

keywords = "Arrhythmias, Heart failure, Ionic, Molecular, Remodeling",

author = "Armoundas, {Antonis A.} and Richard Wu and George Juang and Eduardo Marb{\'a}n and Tomaselli, {Gordon F.}",

note = "Funding Information: Support for this work has been provided by an AHA Fellowship #0020257U (A.A.A), the Stanley J. Sarnoff Endowment for Cardiovascular Science, Inc. Scholar Program (R.W.), and an AHA Fellowship and the International Society for Lung and Heart Transplantation (G.J.). Support for the study of HF and associated sudden death was provided by a Specialized Center of Research grant from the NHLBI, NIH (P50 HL 52307). E.M. holds the Michel Mirowski, M.D. Professorship of Cardiology of the Johns Hopkins University. ",

year = "2001",

doi = "10.1016/S0163-7258(01)00171-1",

language = "English (US)",

volume = "92",

pages = "213--230",

journal = "Pharmacology and Therapeutics",

issn = "0163-7258",

publisher = "Elsevier Inc.",

number = "2-3",

}

TY - JOUR

T1 - Electrical and structural remodeling of the failing ventricle

AU - Armoundas, Antonis A.

AU - Wu, Richard

AU - Juang, George

AU - Marbán, Eduardo

AU - Tomaselli, Gordon F.

N1 - Funding Information: Support for this work has been provided by an AHA Fellowship #0020257U (A.A.A), the Stanley J. Sarnoff Endowment for Cardiovascular Science, Inc. Scholar Program (R.W.), and an AHA Fellowship and the International Society for Lung and Heart Transplantation (G.J.). Support for the study of HF and associated sudden death was provided by a Specialized Center of Research grant from the NHLBI, NIH (P50 HL 52307). E.M. holds the Michel Mirowski, M.D. Professorship of Cardiology of the Johns Hopkins University.

PY - 2001

Y1 - 2001

N2 - Heart failure (HF) is a complex disease that presents a major public health challenge to Western society. The prevalence of HF increases with age in the elderly population, and the societal disease burden will increase with prolongation of life expectancy. HF is initially characterized by an adaptive increase of neurohumoral activation to compensate for reduction of cardiac output. This leads to a combination of neurohumoral activation and mechanical stress in the failing heart that trigger a cascade of maladaptive electrical and structural events that impair both the systolic and diastolic function of the heart.

AB - Heart failure (HF) is a complex disease that presents a major public health challenge to Western society. The prevalence of HF increases with age in the elderly population, and the societal disease burden will increase with prolongation of life expectancy. HF is initially characterized by an adaptive increase of neurohumoral activation to compensate for reduction of cardiac output. This leads to a combination of neurohumoral activation and mechanical stress in the failing heart that trigger a cascade of maladaptive electrical and structural events that impair both the systolic and diastolic function of the heart.

KW - Arrhythmias

KW - Heart failure

KW - Ionic

KW - Molecular

KW - Remodeling

UR - http://www.scopus.com/inward/record.url?scp=0035727695&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035727695&partnerID=8YFLogxK

U2 - 10.1016/S0163-7258(01)00171-1

DO - 10.1016/S0163-7258(01)00171-1

M3 - Review article

C2 - 11916538

AN - SCOPUS:0035727695

SN - 0163-7258

VL - 92

SP - 213

EP - 230

JO - Pharmacology and Therapeutics

JF - Pharmacology and Therapeutics

IS - 2-3

ER -

Electrical and structural remodeling of the failing ventricle

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this