Eighteen new polymorphic markers in the multiple endocrine neoplasia type 1 (MEN1) region

Pachiappan Manickam, Siradanahalli C. Guru, Larisa V. Debelenko, Sunita K. Agarwal, Shodimu Emmanuel Olufemi, Jane M. Weisemann, Mark S. Boguski, Judy S. Crabtree, Yingping Wang, Bruce A. Roe, Irina A. Lubensky, Zhengping Zhuang, Mary Beth Rester, A. Lee Burns, Allen M. Spiegel, Stephen J. Marx, Lance A. Liotta, Michael R. Emmert-Buck, Francis S. Collins, Settara C. Chandrasekharappa

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder in which affected individuals develop tumors primarily in the parathyroids, anterior pituitary, endocrine pancreas, and duodenum. The locus for MEN1 is tightly linked to the marker PYGM on chromosome 11q13, and linkage analysis has previously placed the MEN1 gene within a 2-Mb interval flanked by markers D11S1883 and D11S449. Loss of heterozygosity (LOH) studies in MEN1 and sporadic tumors have helped narrow the location of the gene to a 600-kb interval between PYGM and D11S449. Eighteen new polymerase chain reaction (PCR)-based polymorphic markers were generated for the MEN1 region, with ten mapping to the PYGM-D11S449 interval. These new markers, along with 14 previously known polymorphic markers, were precisely mapped on a 2.8-Mb (D11S480-D11S913) high density clone contig-based, physical map generated for the MEN1 region.

Original languageEnglish (US)
Pages (from-to)102-108
Number of pages7
JournalHuman Genetics
Volume101
Issue number1
DOIs
StatePublished - Dec 1 1997
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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    Manickam, P., Guru, S. C., Debelenko, L. V., Agarwal, S. K., Olufemi, S. E., Weisemann, J. M., Boguski, M. S., Crabtree, J. S., Wang, Y., Roe, B. A., Lubensky, I. A., Zhuang, Z., Rester, M. B., Burns, A. L., Spiegel, A. M., Marx, S. J., Liotta, L. A., Emmert-Buck, M. R., Collins, F. S., & Chandrasekharappa, S. C. (1997). Eighteen new polymorphic markers in the multiple endocrine neoplasia type 1 (MEN1) region. Human Genetics, 101(1), 102-108. https://doi.org/10.1007/s004390050595