Efficiency and fidelity in a click-chemistry route to triazole dendrimers by the copper(I)-catalyzed ligation of azides and alkynes

Peng Wu; Alina K. Feldman; Anne K. Nugent; Craig J. Hawker; Arnulf Scheel; Brigitte Voit; Jeffrey Pyun; Jean M.J. Fréchet; K. Barry Sharpless; Valery V. Fokin

doi:10.1002/anie.200454078

Efficiency and fidelity in a click-chemistry route to triazole dendrimers by the copper(I)-catalyzed ligation of azides and alkynes

Peng Wu, Alina K. Feldman, Anne K. Nugent, Craig J. Hawker, Arnulf Scheel, Brigitte Voit, Jeffrey Pyun, Jean M.J. Fréchet, K. Barry Sharpless, Valery V. Fokin

Research output: Contribution to journal › Article › peer-review

1188 Scopus citations

Abstract

Components that click: A large number of diverse dendrimers (see scheme) was prepared in almost quantitative yield by the click-chemistry transformation described in the title. In some cases filtration or solvent extraction was the only method required for purification in this highly efficient construction of the triazole units of the dendrimers.

Original language	English (US)
Pages (from-to)	3928-3932
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	43
Issue number	30
DOIs	https://doi.org/10.1002/anie.200454078
State	Published - Jul 26 2004
Externally published	Yes

Keywords

Alkynes
Azides
Click chemistry
Copper
Dendrimers

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200454078

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Wu, P., Feldman, A. K., Nugent, A. K., Hawker, C. J., Scheel, A., Voit, B., Pyun, J., Fréchet, J. M. J., Sharpless, K. B., & Fokin, V. V. (2004). Efficiency and fidelity in a click-chemistry route to triazole dendrimers by the copper(I)-catalyzed ligation of azides and alkynes. Angewandte Chemie - International Edition, 43(30), 3928-3932. https://doi.org/10.1002/anie.200454078

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AU - Hawker, Craig J.

AU - Scheel, Arnulf

AU - Voit, Brigitte

AU - Pyun, Jeffrey

AU - Fréchet, Jean M.J.

AU - Sharpless, K. Barry

AU - Fokin, Valery V.

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KW - Click chemistry

KW - Copper

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Efficiency and fidelity in a click-chemistry route to triazole dendrimers by the copper(I)-catalyzed ligation of azides and alkynes

Abstract

Keywords

ASJC Scopus subject areas

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