Efficacy of voriconazole in experimental Cryptococcus neoformans infection

Nikolaos Mavrogiorgos; Oscar Zaragoza; Arturo Casadevall; Joshua D. Nosanchuk

doi:10.1007/s11046-006-0039-4

Efficacy of voriconazole in experimental Cryptococcus neoformans infection

Nikolaos Mavrogiorgos, Oscar Zaragoza, Arturo Casadevall, Joshua D. Nosanchuk

Medicine

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Voriconazole is a third generation triazole with improved activity against many fungal pathogens. We examined the efficacy of voriconazole in a murine infection model and evaluated the drug's effect on cellular characteristics and serum polysaccharide levels. The antifungal reduced serum polysaccharide and significantly prolonged the survival of lethally infected animals.

Original language	English (US)
Pages (from-to)	111-114
Number of pages	4
Journal	Mycopathologia
Volume	162
Issue number	2
DOIs	https://doi.org/10.1007/s11046-006-0039-4
State	Published - Aug 1 2006

Keywords

Antifungal
Cryptococcus neoformans
Polysaccharide capsule
Voriconazole

ASJC Scopus subject areas

Microbiology
Applied Microbiology and Biotechnology
Agronomy and Crop Science
veterinary (miscalleneous)

Access to Document

10.1007/s11046-006-0039-4

Fingerprint Dive into the research topics of 'Efficacy of voriconazole in experimental Cryptococcus neoformans infection'. Together they form a unique fingerprint.

Cite this

@article{fadbbd96e66d49b7a24c53f950923389,

title = "Efficacy of voriconazole in experimental Cryptococcus neoformans infection",

abstract = "Voriconazole is a third generation triazole with improved activity against many fungal pathogens. We examined the efficacy of voriconazole in a murine infection model and evaluated the drug's effect on cellular characteristics and serum polysaccharide levels. The antifungal reduced serum polysaccharide and significantly prolonged the survival of lethally infected animals.",

keywords = "Antifungal, Cryptococcus neoformans, Polysaccharide capsule, Voriconazole",

author = "Nikolaos Mavrogiorgos and Oscar Zaragoza and Arturo Casadevall and Nosanchuk, {Joshua D.}",

year = "2006",

month = aug,

day = "1",

doi = "10.1007/s11046-006-0039-4",

language = "English (US)",

volume = "162",

pages = "111--114",

journal = "Mycopathologia",

issn = "0301-486X",

publisher = "Springer Netherlands",

number = "2",

}

TY - JOUR

T1 - Efficacy of voriconazole in experimental Cryptococcus neoformans infection

AU - Mavrogiorgos, Nikolaos

AU - Zaragoza, Oscar

AU - Casadevall, Arturo

AU - Nosanchuk, Joshua D.

PY - 2006/8/1

Y1 - 2006/8/1

N2 - Voriconazole is a third generation triazole with improved activity against many fungal pathogens. We examined the efficacy of voriconazole in a murine infection model and evaluated the drug's effect on cellular characteristics and serum polysaccharide levels. The antifungal reduced serum polysaccharide and significantly prolonged the survival of lethally infected animals.

AB - Voriconazole is a third generation triazole with improved activity against many fungal pathogens. We examined the efficacy of voriconazole in a murine infection model and evaluated the drug's effect on cellular characteristics and serum polysaccharide levels. The antifungal reduced serum polysaccharide and significantly prolonged the survival of lethally infected animals.

KW - Antifungal

KW - Cryptococcus neoformans

KW - Polysaccharide capsule

KW - Voriconazole

UR - http://www.scopus.com/inward/record.url?scp=33746874842&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746874842&partnerID=8YFLogxK

U2 - 10.1007/s11046-006-0039-4

DO - 10.1007/s11046-006-0039-4

M3 - Article

C2 - 16897589

AN - SCOPUS:33746874842

VL - 162

SP - 111

EP - 114

JO - Mycopathologia

JF - Mycopathologia

SN - 0301-486X

IS - 2

ER -