Efficacy of voriconazole in experimental Cryptococcus neoformans infection

Nikolaos Mavrogiorgos, Oscar Zaragoza, Arturo Casadevall, Joshua D. Nosanchuk

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Voriconazole is a third generation triazole with improved activity against many fungal pathogens. We examined the efficacy of voriconazole in a murine infection model and evaluated the drug's effect on cellular characteristics and serum polysaccharide levels. The antifungal reduced serum polysaccharide and significantly prolonged the survival of lethally infected animals.

Original languageEnglish (US)
Pages (from-to)111-114
Number of pages4
JournalMycopathologia
Volume162
Issue number2
DOIs
Publication statusPublished - Aug 1 2006

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Keywords

  • Antifungal
  • Cryptococcus neoformans
  • Polysaccharide capsule
  • Voriconazole

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology
  • Agronomy and Crop Science
  • veterinary (miscalleneous)

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