Efficacy of voriconazole in experimental Cryptococcus neoformans infection

Nikolaos Mavrogiorgos; Oscar Zaragoza; Arturo Casadevall; Joshua D. Nosanchuk

doi:10.1007/s11046-006-0039-4

Efficacy of voriconazole in experimental Cryptococcus neoformans infection

Nikolaos Mavrogiorgos, Oscar Zaragoza, Arturo Casadevall, Joshua D. Nosanchuk

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Voriconazole is a third generation triazole with improved activity against many fungal pathogens. We examined the efficacy of voriconazole in a murine infection model and evaluated the drug's effect on cellular characteristics and serum polysaccharide levels. The antifungal reduced serum polysaccharide and significantly prolonged the survival of lethally infected animals.

Original language	English (US)
Pages (from-to)	111-114
Number of pages	4
Journal	Mycopathologia
Volume	162
Issue number	2
DOIs	https://doi.org/10.1007/s11046-006-0039-4
State	Published - Aug 2006

Keywords

Antifungal
Cryptococcus neoformans
Polysaccharide capsule
Voriconazole

ASJC Scopus subject areas

Microbiology
Applied Microbiology and Biotechnology
Agronomy and Crop Science
veterinary (miscalleneous)

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10.1007/s11046-006-0039-4

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title = "Efficacy of voriconazole in experimental Cryptococcus neoformans infection",

abstract = "Voriconazole is a third generation triazole with improved activity against many fungal pathogens. We examined the efficacy of voriconazole in a murine infection model and evaluated the drug's effect on cellular characteristics and serum polysaccharide levels. The antifungal reduced serum polysaccharide and significantly prolonged the survival of lethally infected animals.",

keywords = "Antifungal, Cryptococcus neoformans, Polysaccharide capsule, Voriconazole",

author = "Nikolaos Mavrogiorgos and Oscar Zaragoza and Arturo Casadevall and Nosanchuk, {Joshua D.}",

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AU - Mavrogiorgos, Nikolaos

AU - Zaragoza, Oscar

AU - Casadevall, Arturo

AU - Nosanchuk, Joshua D.

PY - 2006/8

Y1 - 2006/8

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AB - Voriconazole is a third generation triazole with improved activity against many fungal pathogens. We examined the efficacy of voriconazole in a murine infection model and evaluated the drug's effect on cellular characteristics and serum polysaccharide levels. The antifungal reduced serum polysaccharide and significantly prolonged the survival of lethally infected animals.

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KW - Cryptococcus neoformans

KW - Polysaccharide capsule

KW - Voriconazole

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ER -

Efficacy of voriconazole in experimental Cryptococcus neoformans infection

Abstract

Keywords

ASJC Scopus subject areas

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