Efficacy of voriconazole in experimental Cryptococcus neoformans infection

Nikolaos Mavrogiorgos; Oscar Zaragoza; Arturo Casadevall; Joshua D. Nosanchuk

doi:10.1007/s11046-006-0039-4

Efficacy of voriconazole in experimental Cryptococcus neoformans infection

Nikolaos Mavrogiorgos, Oscar Zaragoza, Arturo Casadevall, Joshua D. Nosanchuk

Medicine

Research output: Contribution to journal › Article

14 Scopus citations

Abstract

Voriconazole is a third generation triazole with improved activity against many fungal pathogens. We examined the efficacy of voriconazole in a murine infection model and evaluated the drug's effect on cellular characteristics and serum polysaccharide levels. The antifungal reduced serum polysaccharide and significantly prolonged the survival of lethally infected animals.

Original language	English (US)
Pages (from-to)	111-114
Number of pages	4
Journal	Mycopathologia
Volume	162
Issue number	2
DOIs	https://doi.org/10.1007/s11046-006-0039-4
Publication status	Published - Aug 1 2006

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Keywords

Antifungal
Cryptococcus neoformans
Polysaccharide capsule
Voriconazole

ASJC Scopus subject areas

Microbiology
Applied Microbiology and Biotechnology
Agronomy and Crop Science
veterinary (miscalleneous)

Cite this

Mavrogiorgos, N., Zaragoza, O., Casadevall, A., & Nosanchuk, J. D. (2006). Efficacy of voriconazole in experimental Cryptococcus neoformans infection. Mycopathologia, 162(2), 111-114. https://doi.org/10.1007/s11046-006-0039-4

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10.1007/s11046-006-0039-4