Abstract
Voriconazole is a third generation triazole with improved activity against many fungal pathogens. We examined the efficacy of voriconazole in a murine infection model and evaluated the drug's effect on cellular characteristics and serum polysaccharide levels. The antifungal reduced serum polysaccharide and significantly prolonged the survival of lethally infected animals.
Original language | English (US) |
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Pages (from-to) | 111-114 |
Number of pages | 4 |
Journal | Mycopathologia |
Volume | 162 |
Issue number | 2 |
DOIs | |
State | Published - Aug 1 2006 |
Keywords
- Antifungal
- Cryptococcus neoformans
- Polysaccharide capsule
- Voriconazole
ASJC Scopus subject areas
- Microbiology
- Applied Microbiology and Biotechnology
- Agronomy and Crop Science
- veterinary (miscalleneous)