Efficacy of surgical treatment of de novo, adult-onset, cryptogenic, refractory focal status epilepticus

Daniel J. Costello, Mirela V. Simon, Emad N. Eskandar, Matthew P. Frosch, Heidi L. Henninger, Keith H. Chiappa, Andrew J. Cole

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: There have been few published reports of successful surgical treatment of focal status epilepticus. Surgical intervention is considered a last resort after medical strategies have been exhausted. Objective: To report a case of an adult who was initially seen with de novo, medically refractory, cryptogenic focal status epilepticus and underwent resection of an electrographically defined portion of the left middle frontal gyrus with multiple subpial transections of the adjacent cortex resulting in termination of the electroclinical seizure activity. Design: Report of a case of successful surgical treatment of cryptogenic focal status epilepticus. Intervention: After an initial 35 days of oral antiepileptic drug therapy and subsequent 16 days of continuous electroencephalography-guided intravenous antiepileptic drug therapy in an intensive care unit setting, and after extensive preoperative and intraoperative characterization of the epileptogenic zone, a tailored resection of the left middle frontal gyrus with multiple subpial transections of the surrounding cortex was performed. Results: The restricted surgical resection and multiple subpial transections terminated the seizure activity. Neuropathological examination of the resected tissue revealed moderate inflammatory changes and a few abnormally located neurons without any definitive evidence of dysplasia, which was suspected preoperatively. Conclusions: Wesuggest that focal cortical resection may be an appropriate intervention in medically refractory focal status epilepticus even when an overt structural etiology is not evident preoperatively and should be considered as an option at the onset of intractability.

Original languageEnglish (US)
Pages (from-to)895-901
Number of pages7
JournalArchives of Neurology
Volume63
Issue number6
DOIs
StatePublished - Jun 20 2006
Externally publishedYes

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Status Epilepticus
Anticonvulsants
Seizures
Drug Therapy
Intensive Care Units
Electroencephalography
Neurons
Efficacy
Onset
Therapeutics
Cortex
Therapy
Drugs

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Cite this

Costello, D. J., Simon, M. V., Eskandar, E. N., Frosch, M. P., Henninger, H. L., Chiappa, K. H., & Cole, A. J. (2006). Efficacy of surgical treatment of de novo, adult-onset, cryptogenic, refractory focal status epilepticus. Archives of Neurology, 63(6), 895-901. https://doi.org/10.1001/archneur.63.6.895

Efficacy of surgical treatment of de novo, adult-onset, cryptogenic, refractory focal status epilepticus. / Costello, Daniel J.; Simon, Mirela V.; Eskandar, Emad N.; Frosch, Matthew P.; Henninger, Heidi L.; Chiappa, Keith H.; Cole, Andrew J.

In: Archives of Neurology, Vol. 63, No. 6, 20.06.2006, p. 895-901.

Research output: Contribution to journalArticle

Costello, Daniel J. ; Simon, Mirela V. ; Eskandar, Emad N. ; Frosch, Matthew P. ; Henninger, Heidi L. ; Chiappa, Keith H. ; Cole, Andrew J. / Efficacy of surgical treatment of de novo, adult-onset, cryptogenic, refractory focal status epilepticus. In: Archives of Neurology. 2006 ; Vol. 63, No. 6. pp. 895-901.
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