Efficacy of noninvasive ventilation on in-hospital mortality in patients with acute cardiogenic pulmonary edema: a meta-analysis

Tongwen Sun, Youdong Wan, Quancheng Kan, Fei Yang, Haimu Yao, Fangxia Guan, Jinying Zhang, Ling Li

Research output: Contribution to journalArticle

5 Scopus citations


Objective: To evaluate the efficacy of noninvasive ventilation on in-hospital mortality in adult patients with acute cardiogenic pulmonary edema (ACPE). Methods: We searched PubMed, Embase, Wanfang, CNKI data to find relevant randomized controlled trials of noninvasive ventilation for ACPE, which were reported from January 1980 to December 2012. Meta-analysis was performed with software of RevMan 5.1. Results: According to inclusive criteria and exclusion criteria, 35 randomized controlled trials with 3204 patients were enrolled for analyses. Meta-analysis of the trials showed that continuous positive airway pressure (CPAP) reduced in-hospital mortality by 43% (RR=0.57, 95% CI 0.43-0.75, P<0.01) and bilevel positive pressure ventilatio n(BiPAP) reduced mortality by 31% (RR=0.69,95% CI 0.51-0.94, P=0.02) compared with standard therapy. There were no significant differences in in-hospital mortality between BiPAP and CPAP (RR=1.09, 95% CI 0.80-1.49, P=0.57) and myocardial infarction rate (BiPAP vs. CPAP: RR=1.20, 95% CI 0.95-1.52, P=0.12; BiPAP vs. standard therapy: RR=1.10, 95% CI 0.88-1.38, P=0.40). Conclusion: Noninvasive ventilation (BiPAP and CPAP) could reduce in-hospital mortality of adult patients with ACPE, which could be used as first-line management strategies for these patients.

Original languageEnglish (US)
Pages (from-to)161-168
Number of pages8
JournalChinese Journal of Cardiology
Issue number2
Publication statusPublished - Feb 2014



  • Mortality
  • Positive-pressure respiration
  • Pulmonary edema

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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