Efficacy and safety of sotalol in patients with refractory atrial fibrillation or flutter

D. M. Gallik, S. G. Kim, K. J. Ferrick, J. A. Roth, J. D. Fisher

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Sotalol's usefulness in treatment of atrial fibrillation and atrial flutter is unproven. This study evaluated (1) the efficacy of sotalol in preventing recurrences of paroxysmal atrial fibrillation or atrial flutter and controlling ventricular rate (in chronic atrial fibrillation or relapse of paroxysmal atrial arrhythmias), (2) the safety of sotalol, ana (3) predictors of sotalol efficacy. Thirty-three patients, 28 with paroxysmal and five with chronic atrial fibrillation or atrial flutter, received an average dose of 265 ± 119 mg of oral sotalol per day. During a 10 ± 12 month follow-up, recurrence rate for paroxysmal arrhythmia was 64%, with a 50% recurrence at 4.6 months. For patients with chronic atrial fibrillation, ventricular rates were well controlled with sotalol administration (136 ± 33 beats/min versus 88 ± 23 beats/min; p = 0.04). No patient with chronic atrial fibrillation converted to sinus rhythm during the study. Side effects necessitated sotalol discontinuation in three patients. By multi-variate analysis, younger age, higher ejection fraction, and absence of hypertension independently predicted sotalol efficacy.

Original languageEnglish (US)
Pages (from-to)155-160
Number of pages6
JournalAmerican heart journal
Volume134
Issue number2 I
DOIs
StatePublished - Jan 1 1997

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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