Effects of Systemic Methyl Mercury‐Adulterated Water Consumption on Fast Axonal Transport in the Rat Visual System

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Abstract: The present study was designed in an effort to determine whether changes in fast axonal transport in the mature rat visual system can be directly correlated with the onset of neurological dysfunction. Methyl mercury was administered in the drinking water at a concentration of 54 μgHg/ml. Fast axonal transport of proteins in the optic nerve and tract was quantified by scintillation spectrometry of protein‐bound radioactivity along the visual pathway after an intraocular injection of 3H‐proline. At 8 hours after injection the labeled protein had reached the lateral geniculate body both in controls and treated animals. However, two‐way analysis of variance revealed a significant decrease in the volume of transported protein‐bound radioactivity along the visual pathway. Thus, while the rate of fast axonal transport does not seem to be correlated with the onset of motor dysfunction, the onset of neurological symptoms may be associated with abnormal transport capacity. Treatment lowered body weight to the same extent in males and females. Hind limb cross‐over occured after 25.6 ± 0.8 days and was followed quickly by hind limb paralysis (32 ± 0.6 days). The cerebellum revealed pyknotic nuclei throughout the internal granular layer. Purkinje cells appeared normal. No pathological changes were noted in the kidneys. 1986 Nordic Pharmacological Society

Original languageEnglish (US)
Pages (from-to)349-355
Number of pages7
JournalActa Pharmacologica et Toxicologica
Volume59
Issue number5
DOIs
StatePublished - Nov 1986
Externally publishedYes

Keywords

  • Visual system
  • axonal transport
  • methyl mercury
  • protein synthesis
  • rats

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Fingerprint Dive into the research topics of 'Effects of Systemic Methyl Mercury‐Adulterated Water Consumption on Fast Axonal Transport in the Rat Visual System'. Together they form a unique fingerprint.

  • Cite this