Effects of short-term and long-term androgen treatment on the diaphragm in male and female rats

David J. Prezant, D. E. Valentine, E. I. Gentry, B. Richner, J. Cahill, K. Freeman

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The effects of short-term (2.5 wk) and long-term (10 wk) testosterone propionate (2.5 mg/day; 5 days/wk) treatment on diaphragm contractility, fatigue resistance, and fiber type proportions were studied in male and female rats. Contractility and fatigue resistance indexes were measured in an in vitro diaphragm costal strip preparation by direct stimulation at 37°C. The fatigue paradigm consisted of 30 trains/min at 5 Hz (50% duty cycle) for 10 min. Fatigue resistance indexes were calculated as postfatigue divided by baseline forces. In females but not males, testosterone treatment produced significant increases in body weight, costal diaphragm weight, and contractility and significant decreases in fatigue resistance indexes. The interaction between testosterone treatment and the duration of treatment was significant, with the increase in contractility (females) being significant after short-term but not long-term treatment. No significant difference in fiber type proportions or areas was observed, regardless of treatment duration or the preexperimental, basal circulating level of androgen.

Original languageEnglish (US)
Pages (from-to)1140-1149
Number of pages10
JournalJournal of Applied Physiology
Volume75
Issue number3
StatePublished - 1993

Fingerprint

Diaphragm
Androgens
Fatigue
Testosterone
Testosterone Propionate
Body Weight
Weights and Measures

Keywords

  • androgens
  • respiratory muscles
  • sex differences

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Prezant, D. J., Valentine, D. E., Gentry, E. I., Richner, B., Cahill, J., & Freeman, K. (1993). Effects of short-term and long-term androgen treatment on the diaphragm in male and female rats. Journal of Applied Physiology, 75(3), 1140-1149.

Effects of short-term and long-term androgen treatment on the diaphragm in male and female rats. / Prezant, David J.; Valentine, D. E.; Gentry, E. I.; Richner, B.; Cahill, J.; Freeman, K.

In: Journal of Applied Physiology, Vol. 75, No. 3, 1993, p. 1140-1149.

Research output: Contribution to journalArticle

Prezant, DJ, Valentine, DE, Gentry, EI, Richner, B, Cahill, J & Freeman, K 1993, 'Effects of short-term and long-term androgen treatment on the diaphragm in male and female rats', Journal of Applied Physiology, vol. 75, no. 3, pp. 1140-1149.
Prezant, David J. ; Valentine, D. E. ; Gentry, E. I. ; Richner, B. ; Cahill, J. ; Freeman, K. / Effects of short-term and long-term androgen treatment on the diaphragm in male and female rats. In: Journal of Applied Physiology. 1993 ; Vol. 75, No. 3. pp. 1140-1149.
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