Effects of serotonin antagonists on m-chlorophenylpiperazine-mediated responses in normal subjects

RenéS Kahn, Oren Kalus, Scott Wetzler, Wiepke Cahn, Gregory M. Asnis, Herman M. van Praag

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The serotonin (5HT) agonist, m-chlorophenylpiperazine (MCPP), has been used as a challenge agent to assess central 5HT receptor sensitivity in normal subjects and patients with panic disorder, obsessive-compulsive disorder, and major depression. Adrenocorticotropin, cortisol, and prolactin responses to MCPP were among the variables measured. MCPP's usefulness as a probe of 5HT receptors, however, hinges on its 5HT selectivity. To address MCPP's selectivity for 5HT, this study tested whether two different 5HT antagonists, methysergide (4 mg p.o.) and metergoline (4 mg p.o.), could block the hormonal and behavioral effects of MCPP (0.5 mg/kg p.o.) in 10 normal male subjects in comparison to placebo. Both 5HT antagonists abolished the prolactin release to MCPP. Metergoline, the antagonist with the more potent 5HT binding affinity, significantly blocked MCPP's effect on cortisol release as compared to placebo, and methysergide showed a nonsignificant trend to that effect. MCPP alone did not have a significant effect on behavioral variables, perhaps explaining why neither 5HT antagonist affected these measures. The findings from this study suggest that both MCPP-induced prolactin release and cortisol release are indeed 5HT-mediated effects.

Original languageEnglish (US)
Pages (from-to)189-198
Number of pages10
JournalPsychiatry Research
Volume33
Issue number2
DOIs
StatePublished - 1990
Externally publishedYes

Fingerprint

Serotonin Antagonists
Metergoline
Prolactin
Hydrocortisone
Methysergide
Placebos
Serotonin Receptor Agonists
Panic Disorder
Obsessive-Compulsive Disorder
Adrenocorticotropic Hormone
1-(3-chlorophenyl)piperazine
Depression

Keywords

  • hormones
  • m-Chlorophenylpiperazine
  • metergoline
  • methysergide
  • serotonin

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Effects of serotonin antagonists on m-chlorophenylpiperazine-mediated responses in normal subjects. / Kahn, RenéS; Kalus, Oren; Wetzler, Scott; Cahn, Wiepke; Asnis, Gregory M.; van Praag, Herman M.

In: Psychiatry Research, Vol. 33, No. 2, 1990, p. 189-198.

Research output: Contribution to journalArticle

Kahn, RenéS ; Kalus, Oren ; Wetzler, Scott ; Cahn, Wiepke ; Asnis, Gregory M. ; van Praag, Herman M. / Effects of serotonin antagonists on m-chlorophenylpiperazine-mediated responses in normal subjects. In: Psychiatry Research. 1990 ; Vol. 33, No. 2. pp. 189-198.
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