Effects of prenatal exposure to cocaine on the rest-activity cycle of the preweanling rat

Ann C. Zmitrovich, Donald E. Hutchings, Diana L. Dow-Edwards, Daniel Malowany, Sarah H. Church

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Either 45 or 60 mg/kg cocaine HCl was administered from days 8-22 of gestation. Pair-fed and nontreated groups served as controls and all treated and control litters were fostered at birth to untreated dams. To examine whether cocaine produces effects on the rest-activity cycle of the offspring, groups of three littermates from each of the treated and control groups were tested for an 8-h observation period on electronic activity monitors at 22 days of age. Neither activity level nor the rest-activity pattern were affected by cocaine. These findings are discussed in relation to previous studies of cannabis and methadone effects on the rest-activity measure.

Original languageEnglish (US)
Pages (from-to)1059-1064
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume43
Issue number4
DOIs
StatePublished - 1992
Externally publishedYes

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Activity Cycles
Cocaine
Rats
Methadone
Cannabis
Dams
Observation
Parturition
Pregnancy
Control Groups

Keywords

  • Cocaine HCl
  • Developmental toxicity
  • Prenatal
  • Rats
  • Rest-activity cycle

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Effects of prenatal exposure to cocaine on the rest-activity cycle of the preweanling rat. / Zmitrovich, Ann C.; Hutchings, Donald E.; Dow-Edwards, Diana L.; Malowany, Daniel; Church, Sarah H.

In: Pharmacology, Biochemistry and Behavior, Vol. 43, No. 4, 1992, p. 1059-1064.

Research output: Contribution to journalArticle

Zmitrovich, Ann C. ; Hutchings, Donald E. ; Dow-Edwards, Diana L. ; Malowany, Daniel ; Church, Sarah H. / Effects of prenatal exposure to cocaine on the rest-activity cycle of the preweanling rat. In: Pharmacology, Biochemistry and Behavior. 1992 ; Vol. 43, No. 4. pp. 1059-1064.
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