Effects of prenatal exposure to cocaine on the rest-activity cycle of the preweanling rat

Ann C. Zmitrovich, Donald E. Hutchings, Diana L. Dow-Edwards, Daniel Malowany, Sarah Church

Research output: Contribution to journalArticle

10 Scopus citations


Either 45 or 60 mg/kg cocaine HCl was administered from days 8-22 of gestation. Pair-fed and nontreated groups served as controls and all treated and control litters were fostered at birth to untreated dams. To examine whether cocaine produces effects on the rest-activity cycle of the offspring, groups of three littermates from each of the treated and control groups were tested for an 8-h observation period on electronic activity monitors at 22 days of age. Neither activity level nor the rest-activity pattern were affected by cocaine. These findings are discussed in relation to previous studies of cannabis and methadone effects on the rest-activity measure.

Original languageEnglish (US)
Pages (from-to)1059-1064
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Issue number4
Publication statusPublished - Dec 1992
Externally publishedYes



  • Cocaine HCl
  • Developmental toxicity
  • Prenatal
  • Rats
  • Rest-activity cycle

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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