Effects of prenatal exposure to cocaine on the rest-activity cycle of the preweanling rat

Ann C. Zmitrovich; Donald E. Hutchings; Diana L. Dow-Edwards; Daniel Malowany; Sarah Church

doi:10.1016/0091-3057(92)90481-T

Effects of prenatal exposure to cocaine on the rest-activity cycle of the preweanling rat

Ann C. Zmitrovich, Donald E. Hutchings, Diana L. Dow-Edwards, Daniel Malowany, Sarah Church

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Either 45 or 60 mg/kg cocaine HCl was administered from days 8-22 of gestation. Pair-fed and nontreated groups served as controls and all treated and control litters were fostered at birth to untreated dams. To examine whether cocaine produces effects on the rest-activity cycle of the offspring, groups of three littermates from each of the treated and control groups were tested for an 8-h observation period on electronic activity monitors at 22 days of age. Neither activity level nor the rest-activity pattern were affected by cocaine. These findings are discussed in relation to previous studies of cannabis and methadone effects on the rest-activity measure.

Original language	English (US)
Pages (from-to)	1059-1064
Number of pages	6
Journal	Pharmacology, Biochemistry and Behavior
Volume	43
Issue number	4
DOIs	https://doi.org/10.1016/0091-3057(92)90481-T
State	Published - Dec 1992
Externally published	Yes

Keywords

Cocaine HCl
Developmental toxicity
Prenatal
Rats
Rest-activity cycle

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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10.1016/0091-3057(92)90481-T

Cite this

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title = "Effects of prenatal exposure to cocaine on the rest-activity cycle of the preweanling rat",

abstract = "Either 45 or 60 mg/kg cocaine HCl was administered from days 8-22 of gestation. Pair-fed and nontreated groups served as controls and all treated and control litters were fostered at birth to untreated dams. To examine whether cocaine produces effects on the rest-activity cycle of the offspring, groups of three littermates from each of the treated and control groups were tested for an 8-h observation period on electronic activity monitors at 22 days of age. Neither activity level nor the rest-activity pattern were affected by cocaine. These findings are discussed in relation to previous studies of cannabis and methadone effects on the rest-activity measure.",

keywords = "Cocaine HCl, Developmental toxicity, Prenatal, Rats, Rest-activity cycle",

author = "Zmitrovich, {Ann C.} and Hutchings, {Donald E.} and Dow-Edwards, {Diana L.} and Daniel Malowany and Sarah Church",

note = "Funding Information: This research was supported by Grants DA05401 (A.C.Z.), DA03544 (D.E.H.), and DA04118 (D.D.E.) from the National Institute on Drug Abuse.",

year = "1992",

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doi = "10.1016/0091-3057(92)90481-T",

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T1 - Effects of prenatal exposure to cocaine on the rest-activity cycle of the preweanling rat

AU - Zmitrovich, Ann C.

AU - Hutchings, Donald E.

AU - Dow-Edwards, Diana L.

AU - Malowany, Daniel

AU - Church, Sarah

N1 - Funding Information: This research was supported by Grants DA05401 (A.C.Z.), DA03544 (D.E.H.), and DA04118 (D.D.E.) from the National Institute on Drug Abuse.

PY - 1992/12

Y1 - 1992/12

N2 - Either 45 or 60 mg/kg cocaine HCl was administered from days 8-22 of gestation. Pair-fed and nontreated groups served as controls and all treated and control litters were fostered at birth to untreated dams. To examine whether cocaine produces effects on the rest-activity cycle of the offspring, groups of three littermates from each of the treated and control groups were tested for an 8-h observation period on electronic activity monitors at 22 days of age. Neither activity level nor the rest-activity pattern were affected by cocaine. These findings are discussed in relation to previous studies of cannabis and methadone effects on the rest-activity measure.

AB - Either 45 or 60 mg/kg cocaine HCl was administered from days 8-22 of gestation. Pair-fed and nontreated groups served as controls and all treated and control litters were fostered at birth to untreated dams. To examine whether cocaine produces effects on the rest-activity cycle of the offspring, groups of three littermates from each of the treated and control groups were tested for an 8-h observation period on electronic activity monitors at 22 days of age. Neither activity level nor the rest-activity pattern were affected by cocaine. These findings are discussed in relation to previous studies of cannabis and methadone effects on the rest-activity measure.

KW - Cocaine HCl

KW - Developmental toxicity

KW - Prenatal

KW - Rats

KW - Rest-activity cycle

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Effects of prenatal exposure to cocaine on the rest-activity cycle of the preweanling rat

Abstract

Keywords

ASJC Scopus subject areas

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