Effects of Physical Activity Intervention on Physical and Cognitive Function in Sedentary Adults With and Without Diabetes

LIFE Study Investigators

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Type 2 diabetes mellitus may alter the effect of physical activity on physical and cognitive function.

Methods: The Lifestyle Interventions and Independence for Elders (LIFE) trial randomized controlled clinical trial of physical activity intervention (walking, resistance training, and flexibility exercises) enrolled adults aged 70-89 years who were sedentary and non-demented and who had functional limitations. Standardized measures of physical and cognitive function were collected an average of 2 years post-randomization. Differences between the intervention and control groups from 415 individuals with diabetes and 1,061 individuals without diabetes were contrasted with analyses of covariance.

Results: At 24 months, assignment to the physical activity intervention resulted in 0.019 m/s relatively faster average 400-meter gait speeds (p = .007 overall) both for individuals with and without diabetes (intervention × diabetes interaction p = .99). No benefits were seen on scores from a physical performance battery. Performance on cognitive tests was better among participants assigned to the physical activity intervention compared with control only for those with diabetes, particularly for global cognitive function (p = .02) and delayed memory (p = .005), with mean [95% confidence intervals] for benefit from physical activity intervention of 0.114 [0.007,0.111] and 0.208 [0.030,0.387] standard deviations, respectively.

Conclusions: Physical activity intervention improved the gait speed of older, sedentary individuals with and without diabetes. The cognitive function benefits occurred among participants with, but not without, diabetes. The mechanisms through which physical activity affects physical and cognitive function in older adults may differ for individuals by diabetes status.

Original languageEnglish (US)
Pages (from-to)861-866
Number of pages6
JournalThe journals of gerontology. Series A, Biological sciences and medical sciences
Volume72
Issue number6
DOIs
StatePublished - Jun 1 2017

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Cognition
Repression (Psychology)
Resistance Training
Random Allocation
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
Walking
Life Style
Randomized Controlled Trials
Confidence Intervals
Control Groups
Walking Speed

Keywords

  • Behavioral intervention
  • Clinical trials
  • Type 2 diabetes

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

@article{39f87a2c88834c2ab77ba630e7969c15,
title = "Effects of Physical Activity Intervention on Physical and Cognitive Function in Sedentary Adults With and Without Diabetes",
abstract = "Background: Type 2 diabetes mellitus may alter the effect of physical activity on physical and cognitive function.Methods: The Lifestyle Interventions and Independence for Elders (LIFE) trial randomized controlled clinical trial of physical activity intervention (walking, resistance training, and flexibility exercises) enrolled adults aged 70-89 years who were sedentary and non-demented and who had functional limitations. Standardized measures of physical and cognitive function were collected an average of 2 years post-randomization. Differences between the intervention and control groups from 415 individuals with diabetes and 1,061 individuals without diabetes were contrasted with analyses of covariance.Results: At 24 months, assignment to the physical activity intervention resulted in 0.019 m/s relatively faster average 400-meter gait speeds (p = .007 overall) both for individuals with and without diabetes (intervention × diabetes interaction p = .99). No benefits were seen on scores from a physical performance battery. Performance on cognitive tests was better among participants assigned to the physical activity intervention compared with control only for those with diabetes, particularly for global cognitive function (p = .02) and delayed memory (p = .005), with mean [95{\%} confidence intervals] for benefit from physical activity intervention of 0.114 [0.007,0.111] and 0.208 [0.030,0.387] standard deviations, respectively.Conclusions: Physical activity intervention improved the gait speed of older, sedentary individuals with and without diabetes. The cognitive function benefits occurred among participants with, but not without, diabetes. The mechanisms through which physical activity affects physical and cognitive function in older adults may differ for individuals by diabetes status.",
keywords = "Behavioral intervention, Clinical trials, Type 2 diabetes",
author = "{LIFE Study Investigators} and Espeland, {Mark A.} and Kasia Lipska and Miller, {Michael E.} and Julia Rushing and Cohen, {Ronald A.} and Joe Verghese and McDermott, {Mary M.} and King, {Abby C.} and Strotmeyer, {Elsa S.} and Blair, {Steven N.} and Marco Pahor and Kieran Reid and Jamehl Demons and Kritchevsky, {Stephen B.}",
year = "2017",
month = "6",
day = "1",
doi = "10.1093/gerona/glw179",
language = "English (US)",
volume = "72",
pages = "861--866",
journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",
issn = "1079-5006",
publisher = "Oxford University Press",
number = "6",

}

TY - JOUR

T1 - Effects of Physical Activity Intervention on Physical and Cognitive Function in Sedentary Adults With and Without Diabetes

AU - LIFE Study Investigators

AU - Espeland, Mark A.

AU - Lipska, Kasia

AU - Miller, Michael E.

AU - Rushing, Julia

AU - Cohen, Ronald A.

AU - Verghese, Joe

AU - McDermott, Mary M.

AU - King, Abby C.

AU - Strotmeyer, Elsa S.

AU - Blair, Steven N.

AU - Pahor, Marco

AU - Reid, Kieran

AU - Demons, Jamehl

AU - Kritchevsky, Stephen B.

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Background: Type 2 diabetes mellitus may alter the effect of physical activity on physical and cognitive function.Methods: The Lifestyle Interventions and Independence for Elders (LIFE) trial randomized controlled clinical trial of physical activity intervention (walking, resistance training, and flexibility exercises) enrolled adults aged 70-89 years who were sedentary and non-demented and who had functional limitations. Standardized measures of physical and cognitive function were collected an average of 2 years post-randomization. Differences between the intervention and control groups from 415 individuals with diabetes and 1,061 individuals without diabetes were contrasted with analyses of covariance.Results: At 24 months, assignment to the physical activity intervention resulted in 0.019 m/s relatively faster average 400-meter gait speeds (p = .007 overall) both for individuals with and without diabetes (intervention × diabetes interaction p = .99). No benefits were seen on scores from a physical performance battery. Performance on cognitive tests was better among participants assigned to the physical activity intervention compared with control only for those with diabetes, particularly for global cognitive function (p = .02) and delayed memory (p = .005), with mean [95% confidence intervals] for benefit from physical activity intervention of 0.114 [0.007,0.111] and 0.208 [0.030,0.387] standard deviations, respectively.Conclusions: Physical activity intervention improved the gait speed of older, sedentary individuals with and without diabetes. The cognitive function benefits occurred among participants with, but not without, diabetes. The mechanisms through which physical activity affects physical and cognitive function in older adults may differ for individuals by diabetes status.

AB - Background: Type 2 diabetes mellitus may alter the effect of physical activity on physical and cognitive function.Methods: The Lifestyle Interventions and Independence for Elders (LIFE) trial randomized controlled clinical trial of physical activity intervention (walking, resistance training, and flexibility exercises) enrolled adults aged 70-89 years who were sedentary and non-demented and who had functional limitations. Standardized measures of physical and cognitive function were collected an average of 2 years post-randomization. Differences between the intervention and control groups from 415 individuals with diabetes and 1,061 individuals without diabetes were contrasted with analyses of covariance.Results: At 24 months, assignment to the physical activity intervention resulted in 0.019 m/s relatively faster average 400-meter gait speeds (p = .007 overall) both for individuals with and without diabetes (intervention × diabetes interaction p = .99). No benefits were seen on scores from a physical performance battery. Performance on cognitive tests was better among participants assigned to the physical activity intervention compared with control only for those with diabetes, particularly for global cognitive function (p = .02) and delayed memory (p = .005), with mean [95% confidence intervals] for benefit from physical activity intervention of 0.114 [0.007,0.111] and 0.208 [0.030,0.387] standard deviations, respectively.Conclusions: Physical activity intervention improved the gait speed of older, sedentary individuals with and without diabetes. The cognitive function benefits occurred among participants with, but not without, diabetes. The mechanisms through which physical activity affects physical and cognitive function in older adults may differ for individuals by diabetes status.

KW - Behavioral intervention

KW - Clinical trials

KW - Type 2 diabetes

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U2 - 10.1093/gerona/glw179

DO - 10.1093/gerona/glw179

M3 - Article

C2 - 27590629

AN - SCOPUS:85024864154

VL - 72

SP - 861

EP - 866

JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

SN - 1079-5006

IS - 6

ER -