The antitumor drug, bleomycin, interacts with either Fe(II) and O2 or Fe(III) and H2O2 to form an activated complex which attacks DNA. Under aerobic conditions, both reactions yield similar quantities of free bases and products consisting of base plus deoxyribose carbon atoms 1 to 3. Under anaerobic conditions, activated bleomycin releases only free base. The yield of free base is the same under aerobic or anaerobic conditions, provided DNA is furnished in excess. When the DNA concentration is limiting, more base is released under anaerobic than under aerobic conditions. Drug self-destruction proceeds as quickly and completely in the presence or absence of O2.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Biological Chemistry|
|State||Published - 1982|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology