Effects of non-surgical treatment of chronic periodontitis on insulin resistance and glucose tolerance in subjects without diabetes (PARODIA 2 study)

Arnel Redon Nana Nana, Nadia Flore Tsobgny Tsague, Eric Lontchi-Yimagou, Charles Bengondo Messanga, Aurel Tankeu, Jean Claude Katte, Eric Balti Vounsia, Mesmin Dehayem, Eugene Sobngwi

Research output: Contribution to journalArticlepeer-review

Abstract

This study aimed to assess the effects of non-surgical periodontal treatment (NSPT) of chronic periodontitis on insulin sensitivity, glucose tolerance, and serum C reactive protein (CRP) level in individuals without diabetes. Twenty individuals without diabetes with chronic periodontitis underwent NSPT, which consisted of complete scaling, polishing, root planing, and irrigation of the periodontal pockets with a 10% povidone-iodine solution. Periodontal indices (plaque index, gingival bleeding index, pocket depth, and clinical attachment loss), insulin sensitivity using the Short Insulin Tolerance Test index (KITT), glucose tolerance derived from oral glucose tolerance test, and serum CRP level were measured before and 3 months after the intervention. This study was carried out at the National Obesity Center of Yaoundé Central Hospital, Cameroon. After 3 months, we observed significant improvement in periodontal parameters (all p<0.001) and insulin sensitivity (3.72 (2.99-4.17) %/min before treatment vs 4.04 (3.67-4.78) %/min after treatment, p=0.001) and significant decrease in serum CRP level (2.35 (1.46-4.18) mg/L before vs 1.53 (1.03-2.12) mg/L after, p=0.033). There was a trend toward improvement in glucose tolerance, although not statistically significant after the intervention. This study suggests that NSPT of chronic periodontitis in individuals without diabetes is associated with increased insulin sensitivity and decreased serum CRP levels.

Original languageEnglish (US)
Pages (from-to)1377-1381
Number of pages5
JournalJournal of Investigative Medicine
Volume69
Issue number7
DOIs
StatePublished - Oct 1 2021

Keywords

  • glucose metabolism disorders
  • inflammation
  • insulin
  • periodontitis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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