Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis

J. Chan, K. Tanaka, D. Carroll, J. Flynn, B. R. Bloom

Research output: Contribution to journalComment/debate

331 Scopus citations

Abstract

We have recently demonstrated that the macrophage L-arginine-dependent cytotoxic pathway effectively kills the virulent Erdman strain of Mycobacterium tuberculosis in vitro via the generation of toxic reactive nitrogen intermediates by the enzyme nitric oxide synthase. This report demonstrates that two distinct inhibitors of nitric oxide synthase (aminoguanidine and N(G)-monomethyl-L-arginine) render similar deleterious effects on tuberculous infection in mice, as assessed by mortality, bacterial burden, and pathological tissue damage, thus confirming the importance of reactive nitrogen intermediates in resistance against M. tuberculosis.

Original languageEnglish (US)
Pages (from-to)736-740
Number of pages5
JournalInfection and Immunity
Volume63
Issue number2
StatePublished - Jan 1 1995

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ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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