TY - JOUR
T1 - Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis
AU - Chan, J.
AU - Tanaka, K.
AU - Carroll, D.
AU - Flynn, J.
AU - Bloom, B. R.
PY - 1995
Y1 - 1995
N2 - We have recently demonstrated that the macrophage L-arginine-dependent cytotoxic pathway effectively kills the virulent Erdman strain of Mycobacterium tuberculosis in vitro via the generation of toxic reactive nitrogen intermediates by the enzyme nitric oxide synthase. This report demonstrates that two distinct inhibitors of nitric oxide synthase (aminoguanidine and N(G)-monomethyl-L-arginine) render similar deleterious effects on tuberculous infection in mice, as assessed by mortality, bacterial burden, and pathological tissue damage, thus confirming the importance of reactive nitrogen intermediates in resistance against M. tuberculosis.
AB - We have recently demonstrated that the macrophage L-arginine-dependent cytotoxic pathway effectively kills the virulent Erdman strain of Mycobacterium tuberculosis in vitro via the generation of toxic reactive nitrogen intermediates by the enzyme nitric oxide synthase. This report demonstrates that two distinct inhibitors of nitric oxide synthase (aminoguanidine and N(G)-monomethyl-L-arginine) render similar deleterious effects on tuberculous infection in mice, as assessed by mortality, bacterial burden, and pathological tissue damage, thus confirming the importance of reactive nitrogen intermediates in resistance against M. tuberculosis.
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U2 - 10.1128/iai.63.2.736-740.1995
DO - 10.1128/iai.63.2.736-740.1995
M3 - Comment/debate
C2 - 7529749
AN - SCOPUS:0028936417
SN - 0019-9567
VL - 63
SP - 736
EP - 740
JO - Infection and Immunity
JF - Infection and Immunity
IS - 2
ER -