Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis

John Chan, Kathryn E. Tanaka, D. Carroll, J. Flynn, B. R. Bloom

Research output: Contribution to journalArticle

328 Citations (Scopus)

Abstract

We have recently demonstrated that the macrophage L-arginine-dependent cytotoxic pathway effectively kills the virulent Erdman strain of Mycobacterium tuberculosis in vitro via the generation of toxic reactive nitrogen intermediates by the enzyme nitric oxide synthase. This report demonstrates that two distinct inhibitors of nitric oxide synthase (aminoguanidine and N(G)-monomethyl-L-arginine) render similar deleterious effects on tuberculous infection in mice, as assessed by mortality, bacterial burden, and pathological tissue damage, thus confirming the importance of reactive nitrogen intermediates in resistance against M. tuberculosis.

Original languageEnglish (US)
Pages (from-to)736-740
Number of pages5
JournalInfection and Immunity
Volume63
Issue number2
StatePublished - 1995

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Mycobacterium tuberculosis
Nitric Oxide Synthase
Arginine
Nitrogen
Poisons
Infection
Macrophages
Mortality
Enzymes
In Vitro Techniques
pimagedine

ASJC Scopus subject areas

  • Immunology

Cite this

Chan, J., Tanaka, K. E., Carroll, D., Flynn, J., & Bloom, B. R. (1995). Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis. Infection and Immunity, 63(2), 736-740.

Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis. / Chan, John; Tanaka, Kathryn E.; Carroll, D.; Flynn, J.; Bloom, B. R.

In: Infection and Immunity, Vol. 63, No. 2, 1995, p. 736-740.

Research output: Contribution to journalArticle

Chan, J, Tanaka, KE, Carroll, D, Flynn, J & Bloom, BR 1995, 'Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis', Infection and Immunity, vol. 63, no. 2, pp. 736-740.
Chan, John ; Tanaka, Kathryn E. ; Carroll, D. ; Flynn, J. ; Bloom, B. R. / Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis. In: Infection and Immunity. 1995 ; Vol. 63, No. 2. pp. 736-740.
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