Abstract
We have recently demonstrated that the macrophage L-arginine-dependent cytotoxic pathway effectively kills the virulent Erdman strain of Mycobacterium tuberculosis in vitro via the generation of toxic reactive nitrogen intermediates by the enzyme nitric oxide synthase. This report demonstrates that two distinct inhibitors of nitric oxide synthase (aminoguanidine and N(G)-monomethyl-L-arginine) render similar deleterious effects on tuberculous infection in mice, as assessed by mortality, bacterial burden, and pathological tissue damage, thus confirming the importance of reactive nitrogen intermediates in resistance against M. tuberculosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 736-740 |
| Number of pages | 5 |
| Journal | Infection and Immunity |
| Volume | 63 |
| Issue number | 2 |
| State | Published - 1995 |
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ASJC Scopus subject areas
- Immunology
Cite this
Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis. / Chan, John; Tanaka, Kathryn E.; Carroll, D.; Flynn, J.; Bloom, B. R.
In: Infection and Immunity, Vol. 63, No. 2, 1995, p. 736-740.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis
AU - Chan, John
AU - Tanaka, Kathryn E.
AU - Carroll, D.
AU - Flynn, J.
AU - Bloom, B. R.
PY - 1995
Y1 - 1995
N2 - We have recently demonstrated that the macrophage L-arginine-dependent cytotoxic pathway effectively kills the virulent Erdman strain of Mycobacterium tuberculosis in vitro via the generation of toxic reactive nitrogen intermediates by the enzyme nitric oxide synthase. This report demonstrates that two distinct inhibitors of nitric oxide synthase (aminoguanidine and N(G)-monomethyl-L-arginine) render similar deleterious effects on tuberculous infection in mice, as assessed by mortality, bacterial burden, and pathological tissue damage, thus confirming the importance of reactive nitrogen intermediates in resistance against M. tuberculosis.
AB - We have recently demonstrated that the macrophage L-arginine-dependent cytotoxic pathway effectively kills the virulent Erdman strain of Mycobacterium tuberculosis in vitro via the generation of toxic reactive nitrogen intermediates by the enzyme nitric oxide synthase. This report demonstrates that two distinct inhibitors of nitric oxide synthase (aminoguanidine and N(G)-monomethyl-L-arginine) render similar deleterious effects on tuberculous infection in mice, as assessed by mortality, bacterial burden, and pathological tissue damage, thus confirming the importance of reactive nitrogen intermediates in resistance against M. tuberculosis.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028936417&partnerID=8YFLogxK
M3 - Article
C2 - 7529749
AN - SCOPUS:0028936417
VL - 63
SP - 736
EP - 740
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 2
ER -