Effects of MK‐801 and Phenytoin on Flurothyl‐Induced Seizures During Development

Libor Velíšek, Jana Velíšková, Yael Ptachewich, Shlomo Shinnar, Solomon L. Moshé

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Summary We determined the effects of the N‐methyl‐Daspartate (NMDA) receptor blocker MK‐801 (0.05, 0.1, and 0.5 mg/kg intraperitoneally, i.p.) and phenytoin (PHT, 5, 10, and 20 mg/kg i.p.) on flurothyl‐induced clonic and tonic‐clonic seizures in 9‐, 1 5, 30‐, and 60‐day‐old male rats. Both agents had seizure‐, age‐, and dose‐specific effects. The highest dose of MK‐801 was anticonvulsant against clonic flurothyl‐induced seizures only in 9‐ and 60‐day‐old rats, but suppressed tonic‐clonic seizures in all ages. The lowest dose of MK‐801 (0.05 mg/kg) produced significant anticonvulsant effects only in 15 day old rats. PHT did not have any effect on clonic seizures throughout development. Both doses of PHT (10 and 20 mg/kg) were anticonvulsant against tonic‐clonic seizures in adult rats but not in any other age group. The results indicate that NMDA receptors play an important role in tonic‐clonic flurothyl‐induced seizures throughout development (especially in 15‐day‐old rats) and that the anticonvulsant effects of PHT may vary at different stages of brain development.

Original languageEnglish (US)
Pages (from-to)179-185
Number of pages7
JournalEpilepsia
Volume36
Issue number2
DOIs
Publication statusPublished - Feb 1995

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Keywords

  • Anticonvulsants
  • Convulsions
  • Developmental biology
  • Flurothyl
  • MK‐801
  • Phenytoin

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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