Effects of MK-801 and phenytoin on flurothyl-induced seizures during development

L. Velisek, J. Veliskova, Y. Ptachewich, Shlomo Shinnar, Solomon L. Moshe

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We determined the effects of the N-methyl-D-aspartate (NMDA) receptor blocker MK-801 (0.05, 0.1, and 0.5 mg/kg intraperitoneally, i.p.) and phenytoin (PHT, 5, 10, and 20 mg/kg i.p.) on flurothyl-induced clonic and tonic-clonic seizures in 9-, 15-, 30-, and 60-day-old male rats. Both agents had seizure-, age-, and dose-specific effects. The highest dose of MK-801 was anticonvulsant against clonic flurothyl-induced seizures only in 9- and 60- day-old rats, but suppressed tonic-clonic seizures in all ages. The lowest dose of MK-801 (0.05 mg/kg) produced significant anticonvulsant effects only in 15 day old rats. PHT did not have any effect on clonic seizures throughout development. Both doses of PHT (10 and 20 mg/kg) were anticonvulsant against tonic-clonic seizures in adult rats but not in any other age group. The results indicate that NMDA receptors play an important role in tonic-clonic flurothyl-induced seizures throughout development (especially in 15-day-old rats) and that the anticonvulsant effects of PHT may vary at different stages of brain development.

Original languageEnglish (US)
Pages (from-to)179-185
Number of pages7
JournalEpilepsia
Volume36
Issue number2
DOIs
StatePublished - 1995

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Flurothyl
Dizocilpine Maleate
Phenytoin
Seizures
Anticonvulsants
N-Methyl-D-Aspartate Receptors
Age Groups

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Effects of MK-801 and phenytoin on flurothyl-induced seizures during development. / Velisek, L.; Veliskova, J.; Ptachewich, Y.; Shinnar, Shlomo; Moshe, Solomon L.

In: Epilepsia, Vol. 36, No. 2, 1995, p. 179-185.

Research output: Contribution to journalArticle

Velisek, L. ; Veliskova, J. ; Ptachewich, Y. ; Shinnar, Shlomo ; Moshe, Solomon L. / Effects of MK-801 and phenytoin on flurothyl-induced seizures during development. In: Epilepsia. 1995 ; Vol. 36, No. 2. pp. 179-185.
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