Effects of magnetic stimulation on oxidative stress and skeletal muscle regeneration induced by mepivacaine in rat

I. Jimena; I. Tasset; R. López-Martos; A. J. Rubio; E. Luque; P. Montilla; J. Peña; I. Túnez

doi:10.2174/157340609787049217

Effects of magnetic stimulation on oxidative stress and skeletal muscle regeneration induced by mepivacaine in rat

I. Jimena, I. Tasset, R. López-Martos, A. J. Rubio, E. Luque, P. Montilla, J. Peña, I. Túnez

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

We investigated the effect of magnetic field stimulation (MS) on oxidative damage and skeletal muscle injury prompted by mepivacaine injection in the anterior tibial muscle of Wistar rats. The effects of mepivacaine and MS on oxidative stress were evaluated by lipid peroxidation, GSH levels and catalase activity. Muscle regeneration was analyzed by haematoxylin-eosin stained, NADH-TR histochemical reaction, desmin immunostaining as well as by morphometric parameters such as fibers density and fiber area were evaluated. Our data revealed that mepivacaine induced oxidative stress, that MS prevents the harmful effects induced by mepivacaine and that it facilitates the regeneration process of skeletal muscle. In conclusion, the results show the ability of MS to modify skeletal muscle response to mepivacaine.

Original language	English (US)
Pages (from-to)	44-49
Number of pages	6
Journal	Medicinal Chemistry
Volume	5
Issue number	1
DOIs	https://doi.org/10.2174/157340609787049217
State	Published - 2009
Externally published	Yes

Keywords

Magnetic stimulation
Muscle fiber regeneration
Reactive oxygen species
Total nitrite

ASJC Scopus subject areas

Drug Discovery

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10.2174/157340609787049217

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title = "Effects of magnetic stimulation on oxidative stress and skeletal muscle regeneration induced by mepivacaine in rat",

abstract = "We investigated the effect of magnetic field stimulation (MS) on oxidative damage and skeletal muscle injury prompted by mepivacaine injection in the anterior tibial muscle of Wistar rats. The effects of mepivacaine and MS on oxidative stress were evaluated by lipid peroxidation, GSH levels and catalase activity. Muscle regeneration was analyzed by haematoxylin-eosin stained, NADH-TR histochemical reaction, desmin immunostaining as well as by morphometric parameters such as fibers density and fiber area were evaluated. Our data revealed that mepivacaine induced oxidative stress, that MS prevents the harmful effects induced by mepivacaine and that it facilitates the regeneration process of skeletal muscle. In conclusion, the results show the ability of MS to modify skeletal muscle response to mepivacaine.",

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AU - Jimena, I.

AU - Tasset, I.

AU - López-Martos, R.

AU - Rubio, A. J.

AU - Luque, E.

AU - Montilla, P.

AU - Peña, J.

AU - Túnez, I.

PY - 2009

Y1 - 2009

N2 - We investigated the effect of magnetic field stimulation (MS) on oxidative damage and skeletal muscle injury prompted by mepivacaine injection in the anterior tibial muscle of Wistar rats. The effects of mepivacaine and MS on oxidative stress were evaluated by lipid peroxidation, GSH levels and catalase activity. Muscle regeneration was analyzed by haematoxylin-eosin stained, NADH-TR histochemical reaction, desmin immunostaining as well as by morphometric parameters such as fibers density and fiber area were evaluated. Our data revealed that mepivacaine induced oxidative stress, that MS prevents the harmful effects induced by mepivacaine and that it facilitates the regeneration process of skeletal muscle. In conclusion, the results show the ability of MS to modify skeletal muscle response to mepivacaine.

AB - We investigated the effect of magnetic field stimulation (MS) on oxidative damage and skeletal muscle injury prompted by mepivacaine injection in the anterior tibial muscle of Wistar rats. The effects of mepivacaine and MS on oxidative stress were evaluated by lipid peroxidation, GSH levels and catalase activity. Muscle regeneration was analyzed by haematoxylin-eosin stained, NADH-TR histochemical reaction, desmin immunostaining as well as by morphometric parameters such as fibers density and fiber area were evaluated. Our data revealed that mepivacaine induced oxidative stress, that MS prevents the harmful effects induced by mepivacaine and that it facilitates the regeneration process of skeletal muscle. In conclusion, the results show the ability of MS to modify skeletal muscle response to mepivacaine.

KW - Magnetic stimulation

KW - Muscle fiber regeneration

KW - Reactive oxygen species

KW - Total nitrite

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Effects of magnetic stimulation on oxidative stress and skeletal muscle regeneration induced by mepivacaine in rat

Abstract

Keywords

ASJC Scopus subject areas

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