Effects of magnetic stimulation on oxidative stress and skeletal muscle regeneration induced by mepivacaine in rat

I. Jimena, I. Tasset, R. López-Martos, A. J. Rubio, E. Luque, P. Montilla, J. Peña, I. Túnez

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

We investigated the effect of magnetic field stimulation (MS) on oxidative damage and skeletal muscle injury prompted by mepivacaine injection in the anterior tibial muscle of Wistar rats. The effects of mepivacaine and MS on oxidative stress were evaluated by lipid peroxidation, GSH levels and catalase activity. Muscle regeneration was analyzed by haematoxylin-eosin stained, NADH-TR histochemical reaction, desmin immunostaining as well as by morphometric parameters such as fibers density and fiber area were evaluated. Our data revealed that mepivacaine induced oxidative stress, that MS prevents the harmful effects induced by mepivacaine and that it facilitates the regeneration process of skeletal muscle. In conclusion, the results show the ability of MS to modify skeletal muscle response to mepivacaine.

Original languageEnglish (US)
Pages (from-to)44-49
Number of pages6
JournalMedicinal Chemistry
Volume5
Issue number1
DOIs
Publication statusPublished - Sep 18 2009
Externally publishedYes

    Fingerprint

Keywords

  • Magnetic stimulation
  • Muscle fiber regeneration
  • Reactive oxygen species
  • Total nitrite

ASJC Scopus subject areas

  • Drug Discovery

Cite this