Effects of magnetic stimulation on oxidative stress and skeletal muscle regeneration induced by mepivacaine in rat

I. Jimena, Inmaculada Tasset, R. López-Martos, A. J. Rubio, E. Luque, P. Montilla, J. Peña, I. Túnez

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We investigated the effect of magnetic field stimulation (MS) on oxidative damage and skeletal muscle injury prompted by mepivacaine injection in the anterior tibial muscle of Wistar rats. The effects of mepivacaine and MS on oxidative stress were evaluated by lipid peroxidation, GSH levels and catalase activity. Muscle regeneration was analyzed by haematoxylin-eosin stained, NADH-TR histochemical reaction, desmin immunostaining as well as by morphometric parameters such as fibers density and fiber area were evaluated. Our data revealed that mepivacaine induced oxidative stress, that MS prevents the harmful effects induced by mepivacaine and that it facilitates the regeneration process of skeletal muscle. In conclusion, the results show the ability of MS to modify skeletal muscle response to mepivacaine.

Original languageEnglish (US)
Pages (from-to)44-49
Number of pages6
JournalMedicinal Chemistry
Volume5
Issue number1
DOIs
StatePublished - 2009
Externally publishedYes

Fingerprint

Mepivacaine
Regeneration
Magnetic Fields
Skeletal Muscle
Oxidative Stress
Desmin
Hematoxylin
Eosine Yellowish-(YS)
NAD
Catalase
Lipid Peroxidation
Wistar Rats
Muscles
Injections
Wounds and Injuries

Keywords

  • Magnetic stimulation
  • Muscle fiber regeneration
  • Reactive oxygen species
  • Total nitrite

ASJC Scopus subject areas

  • Drug Discovery

Cite this

Effects of magnetic stimulation on oxidative stress and skeletal muscle regeneration induced by mepivacaine in rat. / Jimena, I.; Tasset, Inmaculada; López-Martos, R.; Rubio, A. J.; Luque, E.; Montilla, P.; Peña, J.; Túnez, I.

In: Medicinal Chemistry, Vol. 5, No. 1, 2009, p. 44-49.

Research output: Contribution to journalArticle

Jimena, I. ; Tasset, Inmaculada ; López-Martos, R. ; Rubio, A. J. ; Luque, E. ; Montilla, P. ; Peña, J. ; Túnez, I. / Effects of magnetic stimulation on oxidative stress and skeletal muscle regeneration induced by mepivacaine in rat. In: Medicinal Chemistry. 2009 ; Vol. 5, No. 1. pp. 44-49.
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AU - Montilla, P.

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