Effects of local intracoronary paclitaxel delivery using the Remedy transport catheter on neointimal hyperplasia after stent implantation in a porcine model

Krzysztof Milewski; Aleksander Zurakowski; Jacek Pajak; Lukasz Liszka; Marcin Debinski; Piotr P. Buszman; Motaz Abu Samra; Piotr Dominek; Michael S. Aboodi; Grzegorz L. Kaluza; Pawel Buszman

doi:10.1016/j.carrev.2010.05.002

Effects of local intracoronary paclitaxel delivery using the Remedy transport catheter on neointimal hyperplasia after stent implantation in a porcine model

Krzysztof Milewski, Aleksander Zurakowski, Jacek Pajak, Lukasz Liszka, Marcin Debinski, Piotr P. Buszman, Motaz Abu Samra, Piotr Dominek, Michael S. Aboodi, Grzegorz L. Kaluza, Pawel Buszman

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Purpose: To assess the effects of local paclitaxel delivery using the Remedy catheter on neointimal hyperplasia in a porcine model and compare these results to commercially available BMS and biodegradable polymer-coated paclitaxel-eluting stents (BP-PES). Methods and materials: A total of 31 stents were implanted into coronary arteries of 15 domestic swine including eight BMS, six BP-PES, and 17 BMS after intravasal paclitaxel delivery at doses of 250 μg (LPD250; n=9) and 500 μg (LPD500, n=6). All stents were implanted under quantitative coronary angiography (QCA) guidance to achieve a balloon/artery diameter ratio of 1.15:1.0. Twenty-eight days after the procedure, follow-up coronary angiography was performed, the animals were euthanized, and the coronary arteries harvested for histopathological analysis. Results: At follow-up, QCA analysis revealed that lumen loss was significantly worse in BMS and in both LPD groups in comparison to BP-PES stents (P=02). Histomorphometric analysis showed that the LPD500 group presented the highest percentage of area stenosis, achieving a statistically significant difference in comparison to BMS and BP-PES stents. Conclusion: Our study demonstrates that local paclitaxel delivery using the Remedy transport catheter in the two studied doses (250 and 500 μg) is not effective at neointimal hyperplasia inhibition.

Original language	English (US)
Pages (from-to)	82-89
Number of pages	8
Journal	Cardiovascular Revascularization Medicine
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/j.carrev.2010.05.002
State	Published - Mar 2011
Externally published	Yes

Keywords

Paclitaxel
Porcine
Stent
Transport catheter

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.carrev.2010.05.002

Cite this

Milewski, K., Zurakowski, A., Pajak, J., Liszka, L., Debinski, M., Buszman, P. P., Samra, M. A., Dominek, P., Aboodi, M. S., Kaluza, G. L., & Buszman, P. (2011). Effects of local intracoronary paclitaxel delivery using the Remedy transport catheter on neointimal hyperplasia after stent implantation in a porcine model. Cardiovascular Revascularization Medicine, 12(2), 82-89. https://doi.org/10.1016/j.carrev.2010.05.002

Effects of local intracoronary paclitaxel delivery using the Remedy transport catheter on neointimal hyperplasia after stent implantation in a porcine model. / Milewski, Krzysztof; Zurakowski, Aleksander; Pajak, Jacek et al.
In: Cardiovascular Revascularization Medicine, Vol. 12, No. 2, 03.2011, p. 82-89.

Research output: Contribution to journal › Article › peer-review

Milewski, K, Zurakowski, A, Pajak, J, Liszka, L, Debinski, M, Buszman, PP, Samra, MA, Dominek, P, Aboodi, MS, Kaluza, GL & Buszman, P 2011, 'Effects of local intracoronary paclitaxel delivery using the Remedy transport catheter on neointimal hyperplasia after stent implantation in a porcine model', Cardiovascular Revascularization Medicine, vol. 12, no. 2, pp. 82-89. https://doi.org/10.1016/j.carrev.2010.05.002

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title = "Effects of local intracoronary paclitaxel delivery using the Remedy transport catheter on neointimal hyperplasia after stent implantation in a porcine model",

abstract = "Purpose: To assess the effects of local paclitaxel delivery using the Remedy catheter on neointimal hyperplasia in a porcine model and compare these results to commercially available BMS and biodegradable polymer-coated paclitaxel-eluting stents (BP-PES). Methods and materials: A total of 31 stents were implanted into coronary arteries of 15 domestic swine including eight BMS, six BP-PES, and 17 BMS after intravasal paclitaxel delivery at doses of 250 μg (LPD250; n=9) and 500 μg (LPD500, n=6). All stents were implanted under quantitative coronary angiography (QCA) guidance to achieve a balloon/artery diameter ratio of 1.15:1.0. Twenty-eight days after the procedure, follow-up coronary angiography was performed, the animals were euthanized, and the coronary arteries harvested for histopathological analysis. Results: At follow-up, QCA analysis revealed that lumen loss was significantly worse in BMS and in both LPD groups in comparison to BP-PES stents (P=02). Histomorphometric analysis showed that the LPD500 group presented the highest percentage of area stenosis, achieving a statistically significant difference in comparison to BMS and BP-PES stents. Conclusion: Our study demonstrates that local paclitaxel delivery using the Remedy transport catheter in the two studied doses (250 and 500 μg) is not effective at neointimal hyperplasia inhibition.",

keywords = "Paclitaxel, Porcine, Stent, Transport catheter",

author = "Krzysztof Milewski and Aleksander Zurakowski and Jacek Pajak and Lukasz Liszka and Marcin Debinski and Buszman, {Piotr P.} and Samra, {Motaz Abu} and Piotr Dominek and Aboodi, {Michael S.} and Kaluza, {Grzegorz L.} and Pawel Buszman",

note = "Funding Information: Disclosure: This study was supported by The Polish Committee for Scientific Research (Warszawa, Poland) by supplying financial grant (grant No: 4P05C06828 ) as well as by BALTON, Warszawa, Poland, by supplying free stents to the sites. The experiment was conducted with the consent of the Animal Care and Use Committee of the Medical University of Silesia. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "2011",

month = mar,

doi = "10.1016/j.carrev.2010.05.002",

language = "English (US)",

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T1 - Effects of local intracoronary paclitaxel delivery using the Remedy transport catheter on neointimal hyperplasia after stent implantation in a porcine model

AU - Milewski, Krzysztof

AU - Zurakowski, Aleksander

AU - Pajak, Jacek

AU - Liszka, Lukasz

AU - Debinski, Marcin

AU - Buszman, Piotr P.

AU - Samra, Motaz Abu

AU - Dominek, Piotr

AU - Aboodi, Michael S.

AU - Kaluza, Grzegorz L.

AU - Buszman, Pawel

N1 - Funding Information: Disclosure: This study was supported by The Polish Committee for Scientific Research (Warszawa, Poland) by supplying financial grant (grant No: 4P05C06828 ) as well as by BALTON, Warszawa, Poland, by supplying free stents to the sites. The experiment was conducted with the consent of the Animal Care and Use Committee of the Medical University of Silesia. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 2011/3

Y1 - 2011/3

N2 - Purpose: To assess the effects of local paclitaxel delivery using the Remedy catheter on neointimal hyperplasia in a porcine model and compare these results to commercially available BMS and biodegradable polymer-coated paclitaxel-eluting stents (BP-PES). Methods and materials: A total of 31 stents were implanted into coronary arteries of 15 domestic swine including eight BMS, six BP-PES, and 17 BMS after intravasal paclitaxel delivery at doses of 250 μg (LPD250; n=9) and 500 μg (LPD500, n=6). All stents were implanted under quantitative coronary angiography (QCA) guidance to achieve a balloon/artery diameter ratio of 1.15:1.0. Twenty-eight days after the procedure, follow-up coronary angiography was performed, the animals were euthanized, and the coronary arteries harvested for histopathological analysis. Results: At follow-up, QCA analysis revealed that lumen loss was significantly worse in BMS and in both LPD groups in comparison to BP-PES stents (P=02). Histomorphometric analysis showed that the LPD500 group presented the highest percentage of area stenosis, achieving a statistically significant difference in comparison to BMS and BP-PES stents. Conclusion: Our study demonstrates that local paclitaxel delivery using the Remedy transport catheter in the two studied doses (250 and 500 μg) is not effective at neointimal hyperplasia inhibition.

AB - Purpose: To assess the effects of local paclitaxel delivery using the Remedy catheter on neointimal hyperplasia in a porcine model and compare these results to commercially available BMS and biodegradable polymer-coated paclitaxel-eluting stents (BP-PES). Methods and materials: A total of 31 stents were implanted into coronary arteries of 15 domestic swine including eight BMS, six BP-PES, and 17 BMS after intravasal paclitaxel delivery at doses of 250 μg (LPD250; n=9) and 500 μg (LPD500, n=6). All stents were implanted under quantitative coronary angiography (QCA) guidance to achieve a balloon/artery diameter ratio of 1.15:1.0. Twenty-eight days after the procedure, follow-up coronary angiography was performed, the animals were euthanized, and the coronary arteries harvested for histopathological analysis. Results: At follow-up, QCA analysis revealed that lumen loss was significantly worse in BMS and in both LPD groups in comparison to BP-PES stents (P=02). Histomorphometric analysis showed that the LPD500 group presented the highest percentage of area stenosis, achieving a statistically significant difference in comparison to BMS and BP-PES stents. Conclusion: Our study demonstrates that local paclitaxel delivery using the Remedy transport catheter in the two studied doses (250 and 500 μg) is not effective at neointimal hyperplasia inhibition.

KW - Paclitaxel

KW - Porcine

KW - Stent

KW - Transport catheter

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Effects of local intracoronary paclitaxel delivery using the Remedy transport catheter on neointimal hyperplasia after stent implantation in a porcine model

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