Effects of local intracoronary paclitaxel delivery using the Remedy transport catheter on neointimal hyperplasia after stent implantation in a porcine model

Krzysztof Milewski, Aleksander Zurakowski, Jacek Pajak, Lukasz Liszka, Marcin Debinski, Piotr P. Buszman, Motaz Abu Samra, Piotr Dominek, Michael S. Aboodi, Grzegorz L. Kaluza, Pawel Buszman

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Purpose: To assess the effects of local paclitaxel delivery using the Remedy catheter on neointimal hyperplasia in a porcine model and compare these results to commercially available BMS and biodegradable polymer-coated paclitaxel-eluting stents (BP-PES). Methods and materials: A total of 31 stents were implanted into coronary arteries of 15 domestic swine including eight BMS, six BP-PES, and 17 BMS after intravasal paclitaxel delivery at doses of 250 μg (LPD250; n=9) and 500 μg (LPD500, n=6). All stents were implanted under quantitative coronary angiography (QCA) guidance to achieve a balloon/artery diameter ratio of 1.15:1.0. Twenty-eight days after the procedure, follow-up coronary angiography was performed, the animals were euthanized, and the coronary arteries harvested for histopathological analysis. Results: At follow-up, QCA analysis revealed that lumen loss was significantly worse in BMS and in both LPD groups in comparison to BP-PES stents (P=02). Histomorphometric analysis showed that the LPD500 group presented the highest percentage of area stenosis, achieving a statistically significant difference in comparison to BMS and BP-PES stents. Conclusion: Our study demonstrates that local paclitaxel delivery using the Remedy transport catheter in the two studied doses (250 and 500 μg) is not effective at neointimal hyperplasia inhibition.

Original languageEnglish (US)
Pages (from-to)82-89
Number of pages8
JournalCardiovascular Revascularization Medicine
Volume12
Issue number2
DOIs
StatePublished - Mar 2011
Externally publishedYes

Keywords

  • Paclitaxel
  • Porcine
  • Stent
  • Transport catheter

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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