TY - JOUR
T1 - Effects of labetalol on perioperative stress markers and isoflurane requirements
AU - Amar, D.
AU - Shamoon, H.
AU - Frishman, W. H.
AU - Lazar, E. J.
AU - Salama, M. D.
N1 - Funding Information:
This research was supported in part by Clinical Research Center Grant No. M01-RR-50 and an educational grant by Key Pharmaceuticals.
Funding Information:
H.S. was supported by grants DK 36617 and DK 40501 from the National Institute of Health.
PY - 1991/9
Y1 - 1991/9
N2 - We have studied the effect of labetalol on anaesthetic requirements, cardiac and humoral responses in 16 healthy women during elective abdominal surgery. The experimental group (n = 8) received increments of i.v. labetalol 0.15-0.3mg kg-1 to reduce mean arterial pressure (MAP) by 15% from values obtained before anaesthesia. All patients received thiopentone 6 mg kg-1 and anaesthesia was maintained with isoflurane and nitrous oxide. In the placebo group, trachea/intubation provoked a 33% increase in heart rate (HR) and a 52% increase in MAP (P < 0.001 vs baseline for both). In contrast, pretreatment with labetalol resulted in a 7.3% increase in HR and a 21.3% increase in MAP (P < 0.05 vs baseline for MAP). Two patients treated with labetalol had a reduction in MAP to 50-60 mm Hg during surgery. After trachea/ extubation, the labetalol group had a significantly slower HR than the placebo group (P < 0.05). The cardiovascular response to tracheal intubation was associated with an increase in plasma noradrenane concentration in both groups. Labetalol did not affect isoflurane requirements, plasma concentrations of adrenaline, cortisol and aldosterone or arterial Po2, but prevented the decrease in plasma concentration of potassium which occurred in placebo treated patients (P < 0.05) in early recovery. We conclude that preanaesthetic administration of labetalol attenuated the perioperative hypertensive and tachycardic responses, but was accompanied by intraoperative hypotension when given in doses < 0.5 mg kg-1, despite an increase in plasma noradrenaline concentrations.
AB - We have studied the effect of labetalol on anaesthetic requirements, cardiac and humoral responses in 16 healthy women during elective abdominal surgery. The experimental group (n = 8) received increments of i.v. labetalol 0.15-0.3mg kg-1 to reduce mean arterial pressure (MAP) by 15% from values obtained before anaesthesia. All patients received thiopentone 6 mg kg-1 and anaesthesia was maintained with isoflurane and nitrous oxide. In the placebo group, trachea/intubation provoked a 33% increase in heart rate (HR) and a 52% increase in MAP (P < 0.001 vs baseline for both). In contrast, pretreatment with labetalol resulted in a 7.3% increase in HR and a 21.3% increase in MAP (P < 0.05 vs baseline for MAP). Two patients treated with labetalol had a reduction in MAP to 50-60 mm Hg during surgery. After trachea/ extubation, the labetalol group had a significantly slower HR than the placebo group (P < 0.05). The cardiovascular response to tracheal intubation was associated with an increase in plasma noradrenane concentration in both groups. Labetalol did not affect isoflurane requirements, plasma concentrations of adrenaline, cortisol and aldosterone or arterial Po2, but prevented the decrease in plasma concentration of potassium which occurred in placebo treated patients (P < 0.05) in early recovery. We conclude that preanaesthetic administration of labetalol attenuated the perioperative hypertensive and tachycardic responses, but was accompanied by intraoperative hypotension when given in doses < 0.5 mg kg-1, despite an increase in plasma noradrenaline concentrations.
KW - Anaesthesia: general. Anaesthetics
KW - Hormones: stress response to surgery
KW - Sympathetic nervous system: catecholamines
KW - Sympathotytics: labetalol.
KW - Volatile: isoflurane
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U2 - 10.1093/bja/67.3.296
DO - 10.1093/bja/67.3.296
M3 - Article
C2 - 1911016
AN - SCOPUS:0025816088
SN - 0007-0912
VL - 67
SP - 296
EP - 301
JO - British Journal of Anaesthesia
JF - British Journal of Anaesthesia
IS - 3
ER -