Effects of labetalol on perioperative stress markers and isoflurane requirements

D. Amar, Harry Shamoon, W. H. Frishman, E. J. Lazar, M. D. Salama

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We have studied the effect of labetalol on anaesthetic requirements, cardiac and humoral responses in 16 healthy women during elective abdominal surgery. The experimental group (n = 8) received increments of i.v. labetalol 0.15-0.3mg kg-1 to reduce mean arterial pressure (MAP) by 15% from values obtained before anaesthesia. All patients received thiopentone 6 mg kg-1 and anaesthesia was maintained with isoflurane and nitrous oxide. In the placebo group, trachea/intubation provoked a 33% increase in heart rate (HR) and a 52% increase in MAP (P < 0.001 vs baseline for both). In contrast, pretreatment with labetalol resulted in a 7.3% increase in HR and a 21.3% increase in MAP (P < 0.05 vs baseline for MAP). Two patients treated with labetalol had a reduction in MAP to 50-60 mm Hg during surgery. After trachea/ extubation, the labetalol group had a significantly slower HR than the placebo group (P < 0.05). The cardiovascular response to tracheal intubation was associated with an increase in plasma noradrenane concentration in both groups. Labetalol did not affect isoflurane requirements, plasma concentrations of adrenaline, cortisol and aldosterone or arterial Po2, but prevented the decrease in plasma concentration of potassium which occurred in placebo treated patients (P < 0.05) in early recovery. We conclude that preanaesthetic administration of labetalol attenuated the perioperative hypertensive and tachycardic responses, but was accompanied by intraoperative hypotension when given in doses < 0.5 mg kg-1, despite an increase in plasma noradrenaline concentrations.

Original languageEnglish (US)
Pages (from-to)296-301
Number of pages6
JournalBritish Journal of Anaesthesia
Volume67
Issue number3
DOIs
StatePublished - Sep 1991

Fingerprint

Isoflurane
Labetalol
isoflurane
Heart Rate
Plasma
Arterial Pressure
Requirements
placebos
Plasmas
heart rate
Anesthesia
Surgery
Baseline
anesthesia
Placebos
surgery
Trachea
Cortisol
Intubation
Noradrenaline

Keywords

  • Anaesthesia: general. Anaesthetics
  • Hormones: stress response to surgery
  • Sympathetic nervous system: catecholamines
  • Sympathotytics: labetalol.
  • Volatile: isoflurane

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Anesthesiology and Pain Medicine

Cite this

Effects of labetalol on perioperative stress markers and isoflurane requirements. / Amar, D.; Shamoon, Harry; Frishman, W. H.; Lazar, E. J.; Salama, M. D.

In: British Journal of Anaesthesia, Vol. 67, No. 3, 09.1991, p. 296-301.

Research output: Contribution to journalArticle

Amar, D. ; Shamoon, Harry ; Frishman, W. H. ; Lazar, E. J. ; Salama, M. D. / Effects of labetalol on perioperative stress markers and isoflurane requirements. In: British Journal of Anaesthesia. 1991 ; Vol. 67, No. 3. pp. 296-301.
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