[Effects of hypothyroidism on Goalpha gene expression in hippocampus and dentate gyrus during early development of rat brain].

Dongsheng Cai, Y. Chen, G. Chen, M. Luo

Research output: Contribution to journalArticle

Abstract

To study the expression of Goalpha mRNA in hippocampus and dentate gyrus of 7-day rats with hypothyroidism. We use wistar rat model of hypothyroidism and non-radioactive in situ hybridization technique to observe the changs of Goalpha mRNA levels in hippocampus and dentate gyrus of 7-day rats with or without hypothyroidism. Perinatal hypothyroidism can increase Goalpha mRNA levels in all areas of hippocampus and dentate gyrus of 7-day rats. Thyroid hormone can down-regulate Goalpha gene transcription in hippocampus and dentate gyrus during the early development of rat brain.

Original languageEnglish (US)
Pages (from-to)21-24
Number of pages4
JournalZhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
Volume17
Issue number1
StatePublished - Feb 1 2001
Externally publishedYes

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Dentate Gyrus
Hypothyroidism
Hippocampus
Gene Expression
Brain
Messenger RNA
Thyroid Hormones
In Situ Hybridization
Wistar Rats
Down-Regulation
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "To study the expression of Goalpha mRNA in hippocampus and dentate gyrus of 7-day rats with hypothyroidism. We use wistar rat model of hypothyroidism and non-radioactive in situ hybridization technique to observe the changs of Goalpha mRNA levels in hippocampus and dentate gyrus of 7-day rats with or without hypothyroidism. Perinatal hypothyroidism can increase Goalpha mRNA levels in all areas of hippocampus and dentate gyrus of 7-day rats. Thyroid hormone can down-regulate Goalpha gene transcription in hippocampus and dentate gyrus during the early development of rat brain.",
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T1 - [Effects of hypothyroidism on Goalpha gene expression in hippocampus and dentate gyrus during early development of rat brain].

AU - Cai, Dongsheng

AU - Chen, Y.

AU - Chen, G.

AU - Luo, M.

PY - 2001/2/1

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