[Effects of hypothyroidism on Goalpha gene expression in hippocampus and dentate gyrus during early development of rat brain].

D. S. Cai, Y. Chen, G. Chen, M. Luo

Research output: Contribution to journalArticle

Abstract

To study the expression of Goalpha mRNA in hippocampus and dentate gyrus of 7-day rats with hypothyroidism. We use wistar rat model of hypothyroidism and non-radioactive in situ hybridization technique to observe the changs of Goalpha mRNA levels in hippocampus and dentate gyrus of 7-day rats with or without hypothyroidism. Perinatal hypothyroidism can increase Goalpha mRNA levels in all areas of hippocampus and dentate gyrus of 7-day rats. Thyroid hormone can down-regulate Goalpha gene transcription in hippocampus and dentate gyrus during the early development of rat brain.

Original languageEnglish (US)
Pages (from-to)21-24
Number of pages4
JournalZhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
Volume17
Issue number1
StatePublished - Feb 2001

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ASJC Scopus subject areas

  • Medicine(all)

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