To study the expression of Goalpha mRNA in hippocampus and dentate gyrus of 7-day rats with hypothyroidism. We use wistar rat model of hypothyroidism and non-radioactive in situ hybridization technique to observe the changs of Goalpha mRNA levels in hippocampus and dentate gyrus of 7-day rats with or without hypothyroidism. Perinatal hypothyroidism can increase Goalpha mRNA levels in all areas of hippocampus and dentate gyrus of 7-day rats. Thyroid hormone can down-regulate Goalpha gene transcription in hippocampus and dentate gyrus during the early development of rat brain.
|Original language||English (US)|
|Number of pages||4|
|Journal||Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology|
|State||Published - Feb 2001|
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