Effects of gluten-free, dairy-free diet on childhood nephrotic syndrome and gut microbiota

Natalie Uy, Lauren Graf, Kevin V. Lemley, Frederick J. Kaskel

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Emerging evidence suggests an association between food sensitivity and gut microbiota in children with nephrotic syndrome. Diminished proteinuria resulted from eliminating cow's milk and the use of an oligoantigenic diet which excluded gluten, especially in patients with immune-related conditions, i.e., celiac disease and nephrotic syndrome. The mechanisms underlying the association of diet, gut microbiota, and dysregulation of the immune system are unknown. Gut microbiota is influenced by a number of factors including diet composition and other environmental epigenetic exposures. The imbalance in gut microbiota may be ameliorated by gluten-free and dairy-free diets. Gluten-free diet increased the number of unhealthy bacteria while reducing bacterial-induced cytokine production of IL-10. Thus, gluten-free diet may influence the composition and immune function of gut microbiota and should be considered a possible environmental factor associated with immune-related disease, including nephrotic syndrome. Furthermore, the imbalance of gut microbiota may be related to the development of cow's milk protein allergy. Investigations are needed to fill the gaps in our knowledge concerning the associations between the gut microbiome, environmental exposures, epigenetics, racial influences, and the propensity for immune dysregulation with its inherent risk to the developing individual.

Original languageEnglish (US)
Pages (from-to)252-255
Number of pages4
JournalPediatric Research
Volume77
DOIs
StatePublished - Jan 10 2015

Fingerprint

Glutens
Nephrotic Syndrome
Diet
Gluten-Free Diet
Environmental Exposure
Epigenomics
Milk Hypersensitivity
Milk Proteins
Immune System Diseases
Celiac Disease
Gastrointestinal Microbiome
Proteinuria
Interleukin-10
Immune System
Milk
Cytokines
Bacteria
Food

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

Cite this

Effects of gluten-free, dairy-free diet on childhood nephrotic syndrome and gut microbiota. / Uy, Natalie; Graf, Lauren; Lemley, Kevin V.; Kaskel, Frederick J.

In: Pediatric Research, Vol. 77, 10.01.2015, p. 252-255.

Research output: Contribution to journalArticle

@article{e70ed73af94a4ee4a4efd000aeeb29d4,
title = "Effects of gluten-free, dairy-free diet on childhood nephrotic syndrome and gut microbiota",
abstract = "Emerging evidence suggests an association between food sensitivity and gut microbiota in children with nephrotic syndrome. Diminished proteinuria resulted from eliminating cow's milk and the use of an oligoantigenic diet which excluded gluten, especially in patients with immune-related conditions, i.e., celiac disease and nephrotic syndrome. The mechanisms underlying the association of diet, gut microbiota, and dysregulation of the immune system are unknown. Gut microbiota is influenced by a number of factors including diet composition and other environmental epigenetic exposures. The imbalance in gut microbiota may be ameliorated by gluten-free and dairy-free diets. Gluten-free diet increased the number of unhealthy bacteria while reducing bacterial-induced cytokine production of IL-10. Thus, gluten-free diet may influence the composition and immune function of gut microbiota and should be considered a possible environmental factor associated with immune-related disease, including nephrotic syndrome. Furthermore, the imbalance of gut microbiota may be related to the development of cow's milk protein allergy. Investigations are needed to fill the gaps in our knowledge concerning the associations between the gut microbiome, environmental exposures, epigenetics, racial influences, and the propensity for immune dysregulation with its inherent risk to the developing individual.",
author = "Natalie Uy and Lauren Graf and Lemley, {Kevin V.} and Kaskel, {Frederick J.}",
year = "2015",
month = "1",
day = "10",
doi = "10.1038/pr.2014.159",
language = "English (US)",
volume = "77",
pages = "252--255",
journal = "Pediatric Research",
issn = "0031-3998",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Effects of gluten-free, dairy-free diet on childhood nephrotic syndrome and gut microbiota

AU - Uy, Natalie

AU - Graf, Lauren

AU - Lemley, Kevin V.

AU - Kaskel, Frederick J.

PY - 2015/1/10

Y1 - 2015/1/10

N2 - Emerging evidence suggests an association between food sensitivity and gut microbiota in children with nephrotic syndrome. Diminished proteinuria resulted from eliminating cow's milk and the use of an oligoantigenic diet which excluded gluten, especially in patients with immune-related conditions, i.e., celiac disease and nephrotic syndrome. The mechanisms underlying the association of diet, gut microbiota, and dysregulation of the immune system are unknown. Gut microbiota is influenced by a number of factors including diet composition and other environmental epigenetic exposures. The imbalance in gut microbiota may be ameliorated by gluten-free and dairy-free diets. Gluten-free diet increased the number of unhealthy bacteria while reducing bacterial-induced cytokine production of IL-10. Thus, gluten-free diet may influence the composition and immune function of gut microbiota and should be considered a possible environmental factor associated with immune-related disease, including nephrotic syndrome. Furthermore, the imbalance of gut microbiota may be related to the development of cow's milk protein allergy. Investigations are needed to fill the gaps in our knowledge concerning the associations between the gut microbiome, environmental exposures, epigenetics, racial influences, and the propensity for immune dysregulation with its inherent risk to the developing individual.

AB - Emerging evidence suggests an association between food sensitivity and gut microbiota in children with nephrotic syndrome. Diminished proteinuria resulted from eliminating cow's milk and the use of an oligoantigenic diet which excluded gluten, especially in patients with immune-related conditions, i.e., celiac disease and nephrotic syndrome. The mechanisms underlying the association of diet, gut microbiota, and dysregulation of the immune system are unknown. Gut microbiota is influenced by a number of factors including diet composition and other environmental epigenetic exposures. The imbalance in gut microbiota may be ameliorated by gluten-free and dairy-free diets. Gluten-free diet increased the number of unhealthy bacteria while reducing bacterial-induced cytokine production of IL-10. Thus, gluten-free diet may influence the composition and immune function of gut microbiota and should be considered a possible environmental factor associated with immune-related disease, including nephrotic syndrome. Furthermore, the imbalance of gut microbiota may be related to the development of cow's milk protein allergy. Investigations are needed to fill the gaps in our knowledge concerning the associations between the gut microbiome, environmental exposures, epigenetics, racial influences, and the propensity for immune dysregulation with its inherent risk to the developing individual.

UR - http://www.scopus.com/inward/record.url?scp=84920607663&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84920607663&partnerID=8YFLogxK

U2 - 10.1038/pr.2014.159

DO - 10.1038/pr.2014.159

M3 - Article

VL - 77

SP - 252

EP - 255

JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

ER -