Effects of fenfluramine on plasma homovanillic acid in healthy subjects

Eric Hollander, D. J. Stein, J. B. Saoud, C. M. DeCaria, T. B. Cooper, M. N. Islam, M. R. Liebowitz, M. Stanley

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The specificity of fenfluramine as a pharmacological probe of the serotonin system has been questioned, since animal studies with high dose 1-fenfluramine show increases in striatal levels of the dopamine metabolite homo-vanillic acid. To test the specificity of fenfluramine in humans with clinical doses, we compared plasma homovanillic acid (pHVA) concentration in healthy volunteers after administration of fenfluramine (60 mg) and placebo. There were no significant effects on pHVA, which supports previous findings that at doses used in pharmacological challenge paradigms, the effect of fenfluramine on the dopamine system is insufficient to alter measures of its change.

Original languageEnglish (US)
Pages (from-to)81-84
Number of pages4
JournalJournal of Neural Transmission
Volume90
Issue number1
DOIs
StatePublished - Feb 1992
Externally publishedYes

Fingerprint

Fenfluramine
Homovanillic Acid
Healthy Volunteers
Dopamine
Vanillic Acid
Pharmacology
Corpus Striatum
Serotonin
Placebos

Keywords

  • dopamine
  • Fenfluramine
  • plasma homovanillic acid
  • serotonin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Hollander, E., Stein, D. J., Saoud, J. B., DeCaria, C. M., Cooper, T. B., Islam, M. N., ... Stanley, M. (1992). Effects of fenfluramine on plasma homovanillic acid in healthy subjects. Journal of Neural Transmission, 90(1), 81-84. https://doi.org/10.1007/BF01250520

Effects of fenfluramine on plasma homovanillic acid in healthy subjects. / Hollander, Eric; Stein, D. J.; Saoud, J. B.; DeCaria, C. M.; Cooper, T. B.; Islam, M. N.; Liebowitz, M. R.; Stanley, M.

In: Journal of Neural Transmission, Vol. 90, No. 1, 02.1992, p. 81-84.

Research output: Contribution to journalArticle

Hollander, E, Stein, DJ, Saoud, JB, DeCaria, CM, Cooper, TB, Islam, MN, Liebowitz, MR & Stanley, M 1992, 'Effects of fenfluramine on plasma homovanillic acid in healthy subjects', Journal of Neural Transmission, vol. 90, no. 1, pp. 81-84. https://doi.org/10.1007/BF01250520
Hollander, Eric ; Stein, D. J. ; Saoud, J. B. ; DeCaria, C. M. ; Cooper, T. B. ; Islam, M. N. ; Liebowitz, M. R. ; Stanley, M. / Effects of fenfluramine on plasma homovanillic acid in healthy subjects. In: Journal of Neural Transmission. 1992 ; Vol. 90, No. 1. pp. 81-84.
@article{3258431fb79d41b9bc81be0cd629055e,
title = "Effects of fenfluramine on plasma homovanillic acid in healthy subjects",
abstract = "The specificity of fenfluramine as a pharmacological probe of the serotonin system has been questioned, since animal studies with high dose 1-fenfluramine show increases in striatal levels of the dopamine metabolite homo-vanillic acid. To test the specificity of fenfluramine in humans with clinical doses, we compared plasma homovanillic acid (pHVA) concentration in healthy volunteers after administration of fenfluramine (60 mg) and placebo. There were no significant effects on pHVA, which supports previous findings that at doses used in pharmacological challenge paradigms, the effect of fenfluramine on the dopamine system is insufficient to alter measures of its change.",
keywords = "dopamine, Fenfluramine, plasma homovanillic acid, serotonin",
author = "Eric Hollander and Stein, {D. J.} and Saoud, {J. B.} and DeCaria, {C. M.} and Cooper, {T. B.} and Islam, {M. N.} and Liebowitz, {M. R.} and M. Stanley",
year = "1992",
month = "2",
doi = "10.1007/BF01250520",
language = "English (US)",
volume = "90",
pages = "81--84",
journal = "Journal of Neural Transmission",
issn = "0300-9564",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Effects of fenfluramine on plasma homovanillic acid in healthy subjects

AU - Hollander, Eric

AU - Stein, D. J.

AU - Saoud, J. B.

AU - DeCaria, C. M.

AU - Cooper, T. B.

AU - Islam, M. N.

AU - Liebowitz, M. R.

AU - Stanley, M.

PY - 1992/2

Y1 - 1992/2

N2 - The specificity of fenfluramine as a pharmacological probe of the serotonin system has been questioned, since animal studies with high dose 1-fenfluramine show increases in striatal levels of the dopamine metabolite homo-vanillic acid. To test the specificity of fenfluramine in humans with clinical doses, we compared plasma homovanillic acid (pHVA) concentration in healthy volunteers after administration of fenfluramine (60 mg) and placebo. There were no significant effects on pHVA, which supports previous findings that at doses used in pharmacological challenge paradigms, the effect of fenfluramine on the dopamine system is insufficient to alter measures of its change.

AB - The specificity of fenfluramine as a pharmacological probe of the serotonin system has been questioned, since animal studies with high dose 1-fenfluramine show increases in striatal levels of the dopamine metabolite homo-vanillic acid. To test the specificity of fenfluramine in humans with clinical doses, we compared plasma homovanillic acid (pHVA) concentration in healthy volunteers after administration of fenfluramine (60 mg) and placebo. There were no significant effects on pHVA, which supports previous findings that at doses used in pharmacological challenge paradigms, the effect of fenfluramine on the dopamine system is insufficient to alter measures of its change.

KW - dopamine

KW - Fenfluramine

KW - plasma homovanillic acid

KW - serotonin

UR - http://www.scopus.com/inward/record.url?scp=0026476654&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026476654&partnerID=8YFLogxK

U2 - 10.1007/BF01250520

DO - 10.1007/BF01250520

M3 - Article

C2 - 1466879

AN - SCOPUS:0026476654

VL - 90

SP - 81

EP - 84

JO - Journal of Neural Transmission

JF - Journal of Neural Transmission

SN - 0300-9564

IS - 1

ER -