Effects of fenfluramine on plasma homovanillic acid in healthy subjects

E. Hollander, D. J. Stein, J. B. Saoud, C. M. DeCaria, T. B. Cooper, M. N. Islam, M. R. Liebowitz, M. Stanley

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The specificity of fenfluramine as a pharmacological probe of the serotonin system has been questioned, since animal studies with high dose 1-fenfluramine show increases in striatal levels of the dopamine metabolite homo-vanillic acid. To test the specificity of fenfluramine in humans with clinical doses, we compared plasma homovanillic acid (pHVA) concentration in healthy volunteers after administration of fenfluramine (60 mg) and placebo. There were no significant effects on pHVA, which supports previous findings that at doses used in pharmacological challenge paradigms, the effect of fenfluramine on the dopamine system is insufficient to alter measures of its change.

Original languageEnglish (US)
Pages (from-to)81-84
Number of pages4
JournalJournal of Neural Transmission
Volume90
Issue number1
DOIs
StatePublished - Feb 1 1992
Externally publishedYes

Keywords

  • Fenfluramine
  • dopamine
  • plasma homovanillic acid
  • serotonin

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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  • Cite this

    Hollander, E., Stein, D. J., Saoud, J. B., DeCaria, C. M., Cooper, T. B., Islam, M. N., Liebowitz, M. R., & Stanley, M. (1992). Effects of fenfluramine on plasma homovanillic acid in healthy subjects. Journal of Neural Transmission, 90(1), 81-84. https://doi.org/10.1007/BF01250520