Effects of different carbohydrate diets on cardiac and brain uptake of 18F-FDG in Wistar rats

Wei Bing Miao, Rong Fu Wang, M. Donald Blaufox, Eugene J. Fine, Wade Koba

Research output: Contribution to journalArticle

Abstract

Objective: To assess the effects of different carbohydrate diets on cardiac and brain uptake of 18F-FDG in Wistar rats. Methods: After fed with the standard diet and total energy was kept unchanged, 15 Wistar rats were randomly divided into 3 groups (each n=5); low carbohydrate (LC), intermediate carbohydrate (IC) and high carbohydrate (HC). Each group was fed with every diet for 4 weeks and then underwent MicroPET imaging using 18F-FDG, respectively. Blood samples from tail vein were collected for the analysis of ketone body, glucose, insulin and glucagon on the next day. SUVmax of heart and brain was obtained with computer processing. Results: SUV max of heart was 3.27±0.43 in LC group, 10.92±0.89 in IC, and 10.95±0.81 in HC group; SUVmax of brain was 4.78±0.19 in LC group, 4.04±0.15 in IC group and 3.77±0.24 in HC group. There was difference between LC and the other two groups (P<0.01), whereas no difference was found between IC and HC group. Serum ketone body concentration was (726.10±65.95) μmol/L in LC group, which was 6-7 times higher than that in IC and HC group. Serum ketone body was negatively correlated with cardiac SUVmax (r=-0.764, P<0.001), while positively correlated with the brain SUVmax. No difference of serum glucose, insulin and glucagon was found between two groups. Conclusion: Long-term very low carbohydrate diet makes cardiac uptake of FDG decreased and brain uptake increased.

Original languageEnglish (US)
Pages (from-to)1276-1278
Number of pages3
JournalChinese Journal of Medical Imaging Technology
Volume25
Issue number7
StatePublished - Jul 25 2009

Keywords

  • Brain
  • Carbohydrate
  • Diet
  • Fluorodeoxyglucose F18
  • Heart
  • Rat
  • Tomography, emission computed

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Physiology (medical)

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