Effects of deoxycoformycin in mice. III. A murine model reproducing multi-system pathology of human adenosine deaminase deficiency

H. Ratech, R. Hirschhorn, G. J. Thorbecke

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Adult AKR/J mice were treated with 10 μg/g or 100 μg/g 2'-deoxycoformycin, an adenosine deaminase inhibitor with chemotherapeutic potential. The thymus and adrenal glands were decreased in weight more than any other organ. Histologic and cytofluorographic analyses indicated preferential depletion of peanut-agglutinin-positive, cortical thymocytes, as well as acute, dose-dependent damage to the adrenal cortex and medulla. The effect of 2'-deoxycoformycin on the thymus was proven to be independent of the adrenal glands by use of adrenalectomized mice. Dose-dependent liver necrosis, hemolysis, and leukemoid reactivity were observed. These findings illustrate a differential sensitivity of thymocyte subpopulations and suggests, in addition, preferential sensitivity of certain nonlymphoid tissues to 2'-deoxycoformycin administered in vivo.

Original languageEnglish (US)
Pages (from-to)65-72
Number of pages8
JournalAmerican Journal of Pathology
Volume119
Issue number1
StatePublished - 1985
Externally publishedYes

Fingerprint

Pentostatin
Thymocytes
Pathology
Adrenal Glands
Thymus Gland
Adenosine Deaminase Inhibitors
Inbred AKR Mouse
Peanut Agglutinin
Adrenal Medulla
Adrenal Cortex
Hemolysis
Necrosis
Weights and Measures
Liver
Severe combined immunodeficiency due to adenosine deaminase deficiency
human ADA protein

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Effects of deoxycoformycin in mice. III. A murine model reproducing multi-system pathology of human adenosine deaminase deficiency. / Ratech, H.; Hirschhorn, R.; Thorbecke, G. J.

In: American Journal of Pathology, Vol. 119, No. 1, 1985, p. 65-72.

Research output: Contribution to journalArticle

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