Effects of deoxycoformycin in mice. III. A murine model reproducing multi-system pathology of human adenosine deaminase deficiency

H. Ratech, R. Hirschhorn, G. J. Thorbecke

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Abstract

Adult AKR/J mice were treated with 10 μg/g or 100 μg/g 2'-deoxycoformycin, an adenosine deaminase inhibitor with chemotherapeutic potential. The thymus and adrenal glands were decreased in weight more than any other organ. Histologic and cytofluorographic analyses indicated preferential depletion of peanut-agglutinin-positive, cortical thymocytes, as well as acute, dose-dependent damage to the adrenal cortex and medulla. The effect of 2'-deoxycoformycin on the thymus was proven to be independent of the adrenal glands by use of adrenalectomized mice. Dose-dependent liver necrosis, hemolysis, and leukemoid reactivity were observed. These findings illustrate a differential sensitivity of thymocyte subpopulations and suggests, in addition, preferential sensitivity of certain nonlymphoid tissues to 2'-deoxycoformycin administered in vivo.

Original languageEnglish (US)
Pages (from-to)65-72
Number of pages8
JournalAmerican Journal of Pathology
Volume119
Issue number1
Publication statusPublished - Jan 1 1985

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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