Effects of caffeine treatment for apnea of prematurity on cortical speech-sound differentiation in preterm infants

Nathalie L. Maitre, Jeremy Chan, Ann R. Stark, Warren E. Lambert, Judy L. Aschner, Alexandra P. Key

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Caffeine, standard treatment for apnea of prematurity, improves brainstem auditory processing. We hypothesized that caffeine also improves cortical differentiation of complex speech sounds. We used event-related potential methodology to measure responses to speech-sound contrasts in 45 intensive care neonates, stratified by cumulative exposure as no-, low-, and high-caffeine groups. Sound differentiation in the low-caffeine group and near-term no-caffeine infants was similar with repeated measures analysis of variance controlling for gestational and postnatal age. However, a generalized estimating equation approach demonstrated that, at equivalent postnatal age, differentiation was reduced in the high-caffeine (gestational age 25 weeks) compared to the low-caffeine group (gestational age 28 weeks), reflecting the importance of maturity at birth (Z = 2.77, P <.006). We conclude that caffeine improves measures of auditory processing associated with improved neurodevelopmental outcomes in preterm infants. However, current usage of caffeine for apnea of prematurity cannot fully compensate for the effects of brain immaturity on speech sound processing.

Original languageEnglish (US)
Pages (from-to)307-313
Number of pages7
JournalJournal of Child Neurology
Volume30
Issue number3
DOIs
StatePublished - Mar 26 2015

Fingerprint

Phonetics
Apnea
Caffeine
Premature Infants
Gestational Age
Therapeutics
Critical Care
Evoked Potentials
Brain Stem
Analysis of Variance
Parturition
Newborn Infant
Brain

Keywords

  • auditory
  • caffeine
  • event-related potential
  • neonate
  • preterm

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Effects of caffeine treatment for apnea of prematurity on cortical speech-sound differentiation in preterm infants. / Maitre, Nathalie L.; Chan, Jeremy; Stark, Ann R.; Lambert, Warren E.; Aschner, Judy L.; Key, Alexandra P.

In: Journal of Child Neurology, Vol. 30, No. 3, 26.03.2015, p. 307-313.

Research output: Contribution to journalArticle

Maitre, Nathalie L. ; Chan, Jeremy ; Stark, Ann R. ; Lambert, Warren E. ; Aschner, Judy L. ; Key, Alexandra P. / Effects of caffeine treatment for apnea of prematurity on cortical speech-sound differentiation in preterm infants. In: Journal of Child Neurology. 2015 ; Vol. 30, No. 3. pp. 307-313.
@article{f4bc728b0fdf46d4a05e0d96f1edee5f,
title = "Effects of caffeine treatment for apnea of prematurity on cortical speech-sound differentiation in preterm infants",
abstract = "Caffeine, standard treatment for apnea of prematurity, improves brainstem auditory processing. We hypothesized that caffeine also improves cortical differentiation of complex speech sounds. We used event-related potential methodology to measure responses to speech-sound contrasts in 45 intensive care neonates, stratified by cumulative exposure as no-, low-, and high-caffeine groups. Sound differentiation in the low-caffeine group and near-term no-caffeine infants was similar with repeated measures analysis of variance controlling for gestational and postnatal age. However, a generalized estimating equation approach demonstrated that, at equivalent postnatal age, differentiation was reduced in the high-caffeine (gestational age 25 weeks) compared to the low-caffeine group (gestational age 28 weeks), reflecting the importance of maturity at birth (Z = 2.77, P <.006). We conclude that caffeine improves measures of auditory processing associated with improved neurodevelopmental outcomes in preterm infants. However, current usage of caffeine for apnea of prematurity cannot fully compensate for the effects of brain immaturity on speech sound processing.",
keywords = "auditory, caffeine, event-related potential, neonate, preterm",
author = "Maitre, {Nathalie L.} and Jeremy Chan and Stark, {Ann R.} and Lambert, {Warren E.} and Aschner, {Judy L.} and Key, {Alexandra P.}",
year = "2015",
month = "3",
day = "26",
doi = "10.1177/0883073814538500",
language = "English (US)",
volume = "30",
pages = "307--313",
journal = "Journal of Child Neurology",
issn = "0883-0738",
publisher = "SAGE Publications Inc.",
number = "3",

}

TY - JOUR

T1 - Effects of caffeine treatment for apnea of prematurity on cortical speech-sound differentiation in preterm infants

AU - Maitre, Nathalie L.

AU - Chan, Jeremy

AU - Stark, Ann R.

AU - Lambert, Warren E.

AU - Aschner, Judy L.

AU - Key, Alexandra P.

PY - 2015/3/26

Y1 - 2015/3/26

N2 - Caffeine, standard treatment for apnea of prematurity, improves brainstem auditory processing. We hypothesized that caffeine also improves cortical differentiation of complex speech sounds. We used event-related potential methodology to measure responses to speech-sound contrasts in 45 intensive care neonates, stratified by cumulative exposure as no-, low-, and high-caffeine groups. Sound differentiation in the low-caffeine group and near-term no-caffeine infants was similar with repeated measures analysis of variance controlling for gestational and postnatal age. However, a generalized estimating equation approach demonstrated that, at equivalent postnatal age, differentiation was reduced in the high-caffeine (gestational age 25 weeks) compared to the low-caffeine group (gestational age 28 weeks), reflecting the importance of maturity at birth (Z = 2.77, P <.006). We conclude that caffeine improves measures of auditory processing associated with improved neurodevelopmental outcomes in preterm infants. However, current usage of caffeine for apnea of prematurity cannot fully compensate for the effects of brain immaturity on speech sound processing.

AB - Caffeine, standard treatment for apnea of prematurity, improves brainstem auditory processing. We hypothesized that caffeine also improves cortical differentiation of complex speech sounds. We used event-related potential methodology to measure responses to speech-sound contrasts in 45 intensive care neonates, stratified by cumulative exposure as no-, low-, and high-caffeine groups. Sound differentiation in the low-caffeine group and near-term no-caffeine infants was similar with repeated measures analysis of variance controlling for gestational and postnatal age. However, a generalized estimating equation approach demonstrated that, at equivalent postnatal age, differentiation was reduced in the high-caffeine (gestational age 25 weeks) compared to the low-caffeine group (gestational age 28 weeks), reflecting the importance of maturity at birth (Z = 2.77, P <.006). We conclude that caffeine improves measures of auditory processing associated with improved neurodevelopmental outcomes in preterm infants. However, current usage of caffeine for apnea of prematurity cannot fully compensate for the effects of brain immaturity on speech sound processing.

KW - auditory

KW - caffeine

KW - event-related potential

KW - neonate

KW - preterm

UR - http://www.scopus.com/inward/record.url?scp=84923356704&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923356704&partnerID=8YFLogxK

U2 - 10.1177/0883073814538500

DO - 10.1177/0883073814538500

M3 - Article

VL - 30

SP - 307

EP - 313

JO - Journal of Child Neurology

JF - Journal of Child Neurology

SN - 0883-0738

IS - 3

ER -