Effects of bicarbonate/lactate dialysis solution on the inflammatory response of spontaneous peritonitis in rats undergoing chronic peritoneal dialysis

Krzysztof Pawlaczyk, Clifford J. Holmes, Stanislaw Czekalski, Andrzej Breborowicz, Bengt Lindholm

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: We evaluated the incidence of spontaneous peritonitis as well as the local inflammatory response and macroscopic changes in the peritoneum during the use of a bicarbonate/lactate-buffered (P) solution in comparison to conventional (D) solutions in rats on chronic peritoneal dialysis. Methods: Sixty-three male Wistar rats were implanted with peritoneal catheters. After 7 days, the animals were randomly divided into 2 experimental groups (32 rats in D, 31 rats in P) and infused twice daily over the following 4 weeks. Results: After 14 and 23 days, rats dialyzed with D had a higher peritonitis rate than those dialyzed with P. The median number of days until peritonitis occurred was 22 days for the rats in the D group and 29 days for the rats in the P group. Spontaneously infected rats dialyzed with the D solution had higher scores for adhesion formation. Conclusions: In this animal model, dialysis with P delayed the time to the 1st infection, reduced the overall peritonitis rate and reduced peritonitis-associated peritoneal adhesion formation during chronic peritoneal dialysis.

Original languageEnglish (US)
Pages (from-to)200-208
Number of pages9
JournalBlood Purification
Volume28
Issue number3
DOIs
StatePublished - Oct 2009
Externally publishedYes

Fingerprint

Dialysis Solutions
Peritoneal Dialysis
Bicarbonates
Peritonitis
Lactic Acid
Peritoneum
Wistar Rats
Dialysis
Catheters
Animal Models
Incidence
Infection

Keywords

  • Bicarbonate
  • IL-6
  • Peritoneal dialysis
  • Spontaneous peritonitis

ASJC Scopus subject areas

  • Nephrology
  • Hematology

Cite this

Effects of bicarbonate/lactate dialysis solution on the inflammatory response of spontaneous peritonitis in rats undergoing chronic peritoneal dialysis. / Pawlaczyk, Krzysztof; Holmes, Clifford J.; Czekalski, Stanislaw; Breborowicz, Andrzej; Lindholm, Bengt.

In: Blood Purification, Vol. 28, No. 3, 10.2009, p. 200-208.

Research output: Contribution to journalArticle

Pawlaczyk, Krzysztof ; Holmes, Clifford J. ; Czekalski, Stanislaw ; Breborowicz, Andrzej ; Lindholm, Bengt. / Effects of bicarbonate/lactate dialysis solution on the inflammatory response of spontaneous peritonitis in rats undergoing chronic peritoneal dialysis. In: Blood Purification. 2009 ; Vol. 28, No. 3. pp. 200-208.
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