Abstract
Background: We evaluated the incidence of spontaneous peritonitis as well as the local inflammatory response and macroscopic changes in the peritoneum during the use of a bicarbonate/lactate-buffered (P) solution in comparison to conventional (D) solutions in rats on chronic peritoneal dialysis. Methods: Sixty-three male Wistar rats were implanted with peritoneal catheters. After 7 days, the animals were randomly divided into 2 experimental groups (32 rats in D, 31 rats in P) and infused twice daily over the following 4 weeks. Results: After 14 and 23 days, rats dialyzed with D had a higher peritonitis rate than those dialyzed with P. The median number of days until peritonitis occurred was 22 days for the rats in the D group and 29 days for the rats in the P group. Spontaneously infected rats dialyzed with the D solution had higher scores for adhesion formation. Conclusions: In this animal model, dialysis with P delayed the time to the 1st infection, reduced the overall peritonitis rate and reduced peritonitis-associated peritoneal adhesion formation during chronic peritoneal dialysis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 200-208 |
| Number of pages | 9 |
| Journal | Blood Purification |
| Volume | 28 |
| Issue number | 3 |
| DOIs | |
| State | Published - Oct 2009 |
| Externally published | Yes |
Keywords
- Bicarbonate
- IL-6
- Peritoneal dialysis
- Spontaneous peritonitis
ASJC Scopus subject areas
- Hematology
- Nephrology