Effects of betamethasone on maternal plasma cortiocotropin releasing factor, ACTH and cortisol during pregnancy

Pamela J. Tropper; Robin S. Goland; Sharon L. Wardlaw; Harold E. Fox; Andrew G. Frantz

doi:10.1515/jpme.1987.15.3.221

Effects of betamethasone on maternal plasma cortiocotropin releasing factor, ACTH and cortisol during pregnancy

Pamela J. Tropper, Robin S. Goland, Sharon L. Wardlaw, Harold E. Fox, Andrew G. Frantz

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Corticotropin releasing factor immunoactivity (CRFi) has been identified in the plasma of women in the second half of gestation. There are several lines of evidence supporting a placental source for this hormone. Regulation of placental CRFi is poorly understood. In this study, the effect of a long-acting glucorticoid on the release of placental CRFi was investigated. Eleven women in the third trimester of pregnancy had plasma samples measured for CRFi, ACTH and cortisol before and after receiving 12 mg betamethasone. There was a significant decrease in ACTH (p < 0.05) and cortisol levels (p < 0.01) but no change in CRFi. It is concluded that the secretion of CRFi by the placenta is not inhibited by the administration of betamethasone while maternal levels of cortisol and ACTH are lowered. These results suggest that the acute regulation of placental CRFi is distinct from the regulation of hypothalamic CRF.

Original language	English (US)
Pages (from-to)	221-226
Number of pages	6
Journal	Journal of Perinatal Medicine
Volume	15
Issue number	3
DOIs	https://doi.org/10.1515/jpme.1987.15.3.221
State	Published - 1987
Externally published	Yes

Keywords

ACTH
CRF
betamethasone
corticotropin releasing factor
cortisol
glucocorticoids
placenta
preg-nancy

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1515/jpme.1987.15.3.221

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@article{48a531be4fc34e6aa6f451b028142d33,

title = "Effects of betamethasone on maternal plasma cortiocotropin releasing factor, ACTH and cortisol during pregnancy",

abstract = "Corticotropin releasing factor immunoactivity (CRFi) has been identified in the plasma of women in the second half of gestation. There are several lines of evidence supporting a placental source for this hormone. Regulation of placental CRFi is poorly understood. In this study, the effect of a long-acting glucorticoid on the release of placental CRFi was investigated. Eleven women in the third trimester of pregnancy had plasma samples measured for CRFi, ACTH and cortisol before and after receiving 12 mg betamethasone. There was a significant decrease in ACTH (p < 0.05) and cortisol levels (p < 0.01) but no change in CRFi. It is concluded that the secretion of CRFi by the placenta is not inhibited by the administration of betamethasone while maternal levels of cortisol and ACTH are lowered. These results suggest that the acute regulation of placental CRFi is distinct from the regulation of hypothalamic CRF.",

keywords = "ACTH, CRF, betamethasone, corticotropin releasing factor, cortisol, glucocorticoids, placenta, preg-nancy",

author = "Tropper, {Pamela J.} and Goland, {Robin S.} and Wardlaw, {Sharon L.} and Fox, {Harold E.} and Frantz, {Andrew G.}",

note = "Funding Information: Acknowledgements: This work was supported by USP Health Service Grant HD06585 and 2 P50 HD13063. The authors would like to thank Drs. INGE DYRENFURTH and WYLIE HEMBREE for performing the cortisol determinations.",

year = "1987",

doi = "10.1515/jpme.1987.15.3.221",

language = "English (US)",

volume = "15",

pages = "221--226",

journal = "Journal of Perinatal Medicine",

issn = "0300-5577",

publisher = "Walter de Gruyter GmbH & Co. KG",

number = "3",

}

TY - JOUR

T1 - Effects of betamethasone on maternal plasma cortiocotropin releasing factor, ACTH and cortisol during pregnancy

AU - Tropper, Pamela J.

AU - Goland, Robin S.

AU - Wardlaw, Sharon L.

AU - Fox, Harold E.

AU - Frantz, Andrew G.

N1 - Funding Information: Acknowledgements: This work was supported by USP Health Service Grant HD06585 and 2 P50 HD13063. The authors would like to thank Drs. INGE DYRENFURTH and WYLIE HEMBREE for performing the cortisol determinations.

PY - 1987

Y1 - 1987

N2 - Corticotropin releasing factor immunoactivity (CRFi) has been identified in the plasma of women in the second half of gestation. There are several lines of evidence supporting a placental source for this hormone. Regulation of placental CRFi is poorly understood. In this study, the effect of a long-acting glucorticoid on the release of placental CRFi was investigated. Eleven women in the third trimester of pregnancy had plasma samples measured for CRFi, ACTH and cortisol before and after receiving 12 mg betamethasone. There was a significant decrease in ACTH (p < 0.05) and cortisol levels (p < 0.01) but no change in CRFi. It is concluded that the secretion of CRFi by the placenta is not inhibited by the administration of betamethasone while maternal levels of cortisol and ACTH are lowered. These results suggest that the acute regulation of placental CRFi is distinct from the regulation of hypothalamic CRF.

AB - Corticotropin releasing factor immunoactivity (CRFi) has been identified in the plasma of women in the second half of gestation. There are several lines of evidence supporting a placental source for this hormone. Regulation of placental CRFi is poorly understood. In this study, the effect of a long-acting glucorticoid on the release of placental CRFi was investigated. Eleven women in the third trimester of pregnancy had plasma samples measured for CRFi, ACTH and cortisol before and after receiving 12 mg betamethasone. There was a significant decrease in ACTH (p < 0.05) and cortisol levels (p < 0.01) but no change in CRFi. It is concluded that the secretion of CRFi by the placenta is not inhibited by the administration of betamethasone while maternal levels of cortisol and ACTH are lowered. These results suggest that the acute regulation of placental CRFi is distinct from the regulation of hypothalamic CRF.

KW - ACTH

KW - CRF

KW - betamethasone

KW - corticotropin releasing factor

KW - cortisol

KW - glucocorticoids

KW - placenta

KW - preg-nancy

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Effects of betamethasone on maternal plasma cortiocotropin releasing factor, ACTH and cortisol during pregnancy

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Keywords

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