Effects of bacterial vaginosis and other genital infections on the natural history of human papillomavirus infection in HIV-1-infected and high-risk HIV-1-uninfected women

D. Heather Watts, Melissa Fazarri, Howard Minkoff, Sharon L. Hillier, Beverly Sha, Marshall Glesby, Alexandra M. Levine, Robert D. Burk, Joel M. Palefsky, Michael Moxley, Linda Ahdieh-Grant, Howard Strickler

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

Background. Whether the natural history of human papillomavirus (HPV) infection is affected by bacterial vaginosis (BV) or Trichomonas vaginalis (TV) infection has not been adequately investigated in prospective studies. Methods. Human immunodeficiency virus 1 (HIV-1)-infected (n = 1763) and high-risk HIV-1-uninfected (n = 493) women were assessed semiannually for BV (by Nugent's criteria), TV infection (by wet mount), type-specific HPV (by polymerase chain reaction with MY09/MY11/HMB01 HPV primers), and squamous intraepithelial lesions (SIL) (by cytological examination). Sexual history was obtained from patient report at each visit. Risk factors for prevalent and incident HPV infection and SIL were evaluated by use of multivariate models. Results. BV was associated with both prevalent and incident HPV infection but not with duration of HPV infection or incidence of SIL. TV infection was associated with incident HPV infection and with decreased duration and lower prevalence of HPV infection. TV infection had no association with development of SIL. Effects of BV and TV infection were similar in HIV-1-infected and high-risk HIV-1-uninfected women. HIV-1 infection and low CD4+ lymphocyte count were strongly associated with HPV infection and development of SIL. Conclusions. BV and TV infection may increase the risk of acquisition (or reactivation) of HPV infection, as is consistent with hypotheses that the local cervicovaginal milieu plays a role in susceptibility to HPV infection. The finding that BV did not affect persistence of HPV infection and that TV infection may shorten the duration of HPV infection helps explain the lack of effect that BV and TV infection have on development of SIL.

Original languageEnglish (US)
Pages (from-to)1129-1139
Number of pages11
JournalJournal of Infectious Diseases
Volume191
Issue number7
DOIs
StatePublished - Apr 1 2005

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Bacterial Vaginosis
Papillomavirus Infections
Trichomonas Infections
HIV-1
Trichomonas vaginalis
Infection
Virus Diseases
CD4 Lymphocyte Count
Squamous Intraepithelial Lesions of the Cervix

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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Effects of bacterial vaginosis and other genital infections on the natural history of human papillomavirus infection in HIV-1-infected and high-risk HIV-1-uninfected women. / Watts, D. Heather; Fazarri, Melissa; Minkoff, Howard; Hillier, Sharon L.; Sha, Beverly; Glesby, Marshall; Levine, Alexandra M.; Burk, Robert D.; Palefsky, Joel M.; Moxley, Michael; Ahdieh-Grant, Linda; Strickler, Howard.

In: Journal of Infectious Diseases, Vol. 191, No. 7, 01.04.2005, p. 1129-1139.

Research output: Contribution to journalArticle

Watts, D. Heather ; Fazarri, Melissa ; Minkoff, Howard ; Hillier, Sharon L. ; Sha, Beverly ; Glesby, Marshall ; Levine, Alexandra M. ; Burk, Robert D. ; Palefsky, Joel M. ; Moxley, Michael ; Ahdieh-Grant, Linda ; Strickler, Howard. / Effects of bacterial vaginosis and other genital infections on the natural history of human papillomavirus infection in HIV-1-infected and high-risk HIV-1-uninfected women. In: Journal of Infectious Diseases. 2005 ; Vol. 191, No. 7. pp. 1129-1139.
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abstract = "Background. Whether the natural history of human papillomavirus (HPV) infection is affected by bacterial vaginosis (BV) or Trichomonas vaginalis (TV) infection has not been adequately investigated in prospective studies. Methods. Human immunodeficiency virus 1 (HIV-1)-infected (n = 1763) and high-risk HIV-1-uninfected (n = 493) women were assessed semiannually for BV (by Nugent's criteria), TV infection (by wet mount), type-specific HPV (by polymerase chain reaction with MY09/MY11/HMB01 HPV primers), and squamous intraepithelial lesions (SIL) (by cytological examination). Sexual history was obtained from patient report at each visit. Risk factors for prevalent and incident HPV infection and SIL were evaluated by use of multivariate models. Results. BV was associated with both prevalent and incident HPV infection but not with duration of HPV infection or incidence of SIL. TV infection was associated with incident HPV infection and with decreased duration and lower prevalence of HPV infection. TV infection had no association with development of SIL. Effects of BV and TV infection were similar in HIV-1-infected and high-risk HIV-1-uninfected women. HIV-1 infection and low CD4+ lymphocyte count were strongly associated with HPV infection and development of SIL. Conclusions. BV and TV infection may increase the risk of acquisition (or reactivation) of HPV infection, as is consistent with hypotheses that the local cervicovaginal milieu plays a role in susceptibility to HPV infection. The finding that BV did not affect persistence of HPV infection and that TV infection may shorten the duration of HPV infection helps explain the lack of effect that BV and TV infection have on development of SIL.",
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T1 - Effects of bacterial vaginosis and other genital infections on the natural history of human papillomavirus infection in HIV-1-infected and high-risk HIV-1-uninfected women

AU - Watts, D. Heather

AU - Fazarri, Melissa

AU - Minkoff, Howard

AU - Hillier, Sharon L.

AU - Sha, Beverly

AU - Glesby, Marshall

AU - Levine, Alexandra M.

AU - Burk, Robert D.

AU - Palefsky, Joel M.

AU - Moxley, Michael

AU - Ahdieh-Grant, Linda

AU - Strickler, Howard

PY - 2005/4/1

Y1 - 2005/4/1

N2 - Background. Whether the natural history of human papillomavirus (HPV) infection is affected by bacterial vaginosis (BV) or Trichomonas vaginalis (TV) infection has not been adequately investigated in prospective studies. Methods. Human immunodeficiency virus 1 (HIV-1)-infected (n = 1763) and high-risk HIV-1-uninfected (n = 493) women were assessed semiannually for BV (by Nugent's criteria), TV infection (by wet mount), type-specific HPV (by polymerase chain reaction with MY09/MY11/HMB01 HPV primers), and squamous intraepithelial lesions (SIL) (by cytological examination). Sexual history was obtained from patient report at each visit. Risk factors for prevalent and incident HPV infection and SIL were evaluated by use of multivariate models. Results. BV was associated with both prevalent and incident HPV infection but not with duration of HPV infection or incidence of SIL. TV infection was associated with incident HPV infection and with decreased duration and lower prevalence of HPV infection. TV infection had no association with development of SIL. Effects of BV and TV infection were similar in HIV-1-infected and high-risk HIV-1-uninfected women. HIV-1 infection and low CD4+ lymphocyte count were strongly associated with HPV infection and development of SIL. Conclusions. BV and TV infection may increase the risk of acquisition (or reactivation) of HPV infection, as is consistent with hypotheses that the local cervicovaginal milieu plays a role in susceptibility to HPV infection. The finding that BV did not affect persistence of HPV infection and that TV infection may shorten the duration of HPV infection helps explain the lack of effect that BV and TV infection have on development of SIL.

AB - Background. Whether the natural history of human papillomavirus (HPV) infection is affected by bacterial vaginosis (BV) or Trichomonas vaginalis (TV) infection has not been adequately investigated in prospective studies. Methods. Human immunodeficiency virus 1 (HIV-1)-infected (n = 1763) and high-risk HIV-1-uninfected (n = 493) women were assessed semiannually for BV (by Nugent's criteria), TV infection (by wet mount), type-specific HPV (by polymerase chain reaction with MY09/MY11/HMB01 HPV primers), and squamous intraepithelial lesions (SIL) (by cytological examination). Sexual history was obtained from patient report at each visit. Risk factors for prevalent and incident HPV infection and SIL were evaluated by use of multivariate models. Results. BV was associated with both prevalent and incident HPV infection but not with duration of HPV infection or incidence of SIL. TV infection was associated with incident HPV infection and with decreased duration and lower prevalence of HPV infection. TV infection had no association with development of SIL. Effects of BV and TV infection were similar in HIV-1-infected and high-risk HIV-1-uninfected women. HIV-1 infection and low CD4+ lymphocyte count were strongly associated with HPV infection and development of SIL. Conclusions. BV and TV infection may increase the risk of acquisition (or reactivation) of HPV infection, as is consistent with hypotheses that the local cervicovaginal milieu plays a role in susceptibility to HPV infection. The finding that BV did not affect persistence of HPV infection and that TV infection may shorten the duration of HPV infection helps explain the lack of effect that BV and TV infection have on development of SIL.

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