Effects of antifibrinolytic and steroid therapy on the contused spinal cord of cats

J. B. Campbell, V. DeCrescito, J. J. Tomasula, H. B. Demopoulos, Eugene S. Flamm, B. D. Ortega

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A 400 gm/cm force exerted on the exposed spinal cord of the cat led to its progressive destruction by hemorrhage and edema. Intravenous administration of epsilon aminocaproic acid (EACA) and methyl prednisolone sodium succinate (MP) appreciably protected the tissue of the spinal cord by minimizing hemorrhage and edema. At 24 hr a spinal cord so treated compared favorably with an untreated control specimen removed 2 min after trauma. Success with this combined medication was attributed to steroid stabilization of neural cell membranes and the lysosomes contained therein. Thus, edema was partially prevented, as well as escape of proteolytic enzymes. It was the latter group of enzymes that led to propagation of hemorrhages and nervous tissue destruction; EACA inhibited their action.

Original languageEnglish (US)
Pages (from-to)726-733
Number of pages8
JournalJournal of Neurosurgery
Volume40
Issue number6
StatePublished - 1974
Externally publishedYes

Fingerprint

Antifibrinolytic Agents
Contusions
Aminocaproic Acid
Edema
Spinal Cord
Cats
Steroids
Hemorrhage
Nerve Tissue
Lysosomes
Intravenous Administration
Peptide Hydrolases
Therapeutics
Cell Membrane
Wounds and Injuries
Enzymes

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Campbell, J. B., DeCrescito, V., Tomasula, J. J., Demopoulos, H. B., Flamm, E. S., & Ortega, B. D. (1974). Effects of antifibrinolytic and steroid therapy on the contused spinal cord of cats. Journal of Neurosurgery, 40(6), 726-733.

Effects of antifibrinolytic and steroid therapy on the contused spinal cord of cats. / Campbell, J. B.; DeCrescito, V.; Tomasula, J. J.; Demopoulos, H. B.; Flamm, Eugene S.; Ortega, B. D.

In: Journal of Neurosurgery, Vol. 40, No. 6, 1974, p. 726-733.

Research output: Contribution to journalArticle

Campbell, JB, DeCrescito, V, Tomasula, JJ, Demopoulos, HB, Flamm, ES & Ortega, BD 1974, 'Effects of antifibrinolytic and steroid therapy on the contused spinal cord of cats', Journal of Neurosurgery, vol. 40, no. 6, pp. 726-733.
Campbell JB, DeCrescito V, Tomasula JJ, Demopoulos HB, Flamm ES, Ortega BD. Effects of antifibrinolytic and steroid therapy on the contused spinal cord of cats. Journal of Neurosurgery. 1974;40(6):726-733.
Campbell, J. B. ; DeCrescito, V. ; Tomasula, J. J. ; Demopoulos, H. B. ; Flamm, Eugene S. ; Ortega, B. D. / Effects of antifibrinolytic and steroid therapy on the contused spinal cord of cats. In: Journal of Neurosurgery. 1974 ; Vol. 40, No. 6. pp. 726-733.
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