Effects of β-carotene and other factors on outcome of cervical dysplasia and human papillomavirus infection

Seymour L. Romney, Gloria Y F Ho, Prabhudas R. Palan, Jayasri Basu, Anna S. Kadish, Sara Klein, Magdy Mikhail, Robert J. Hagan, Chee Jen Chang, Robert D. Burk

Research output: Contribution to journalArticle

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Abstract

Women with histopathologically confirmed cervical intraepithelial neoplasia (CIN) were followed at 3-month intervals in a randomized double- blinded trial to evaluate the efficacy of β-carotene to cause regression of CIN. Questionnaire data, plasma levels of micronutrients, and a cervicovaginal lavage for human papillomavirus (HPV) detection were obtained at each visit, and an endpoint biopsy was performed at 9 months. Sixty-nine subjects had a biopsy endpoint evaluation; 9 of 39 (23%) subjects in the β- carotene group versus 14 of 30 (47%) in the placebo group had regression of CIN (P = 0.039). Independent risk factors for persistent CIN at 9 months included type-specific persistent HPV infection (OR = 11.38, P = 0.006) and continual HPV infection with a high viral load (OR = 14.25, P = 0.007) at baseline and 9 months, an initial diagnosis of ≤CIN II (OR = 6.74, P = 0.016), and older age (OR for ≤25 years = 4.10, P = 0.072). After controlling for these factors, the β-carotene and placebo groups did not differ in risk for having CIN at 9 months (OR = 1.53, P = 0.550). Resolution of baseline HPV infection was significantly correlated with non-high-risk HPV types (RR = 2.94, P = 0.015), age <25 years (RR = 2.62, P = 0.014), and douching after sexual intercourse (RR = 3.02, P = 0.012), but not with randomization group. Our data indicate that a large proportion of mild CIN lesions regress; age and HPV infection play an important role in the natural course of CIN; and repeated HPV testing may have a value in distinguishing women who need aggressive treatment for CIN versus those who do not. Supplementation of β-carotene does not appear to have a detectable benefit in treatment of CIN.

Original languageEnglish (US)
Pages (from-to)483-492
Number of pages10
JournalGynecologic Oncology
Volume65
Issue number3
DOIs
StatePublished - Jun 1997

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Uterine Cervical Dysplasia
Cervical Intraepithelial Neoplasia
Papillomavirus Infections
Carotenoids
Therapeutic Irrigation
Placebos
Biopsy
Micronutrients
Coitus
Random Allocation
Viral Load

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Effects of β-carotene and other factors on outcome of cervical dysplasia and human papillomavirus infection. / Romney, Seymour L.; Ho, Gloria Y F; Palan, Prabhudas R.; Basu, Jayasri; Kadish, Anna S.; Klein, Sara; Mikhail, Magdy; Hagan, Robert J.; Chang, Chee Jen; Burk, Robert D.

In: Gynecologic Oncology, Vol. 65, No. 3, 06.1997, p. 483-492.

Research output: Contribution to journalArticle

Romney, SL, Ho, GYF, Palan, PR, Basu, J, Kadish, AS, Klein, S, Mikhail, M, Hagan, RJ, Chang, CJ & Burk, RD 1997, 'Effects of β-carotene and other factors on outcome of cervical dysplasia and human papillomavirus infection', Gynecologic Oncology, vol. 65, no. 3, pp. 483-492. https://doi.org/10.1006/gyno.1997.4697
Romney, Seymour L. ; Ho, Gloria Y F ; Palan, Prabhudas R. ; Basu, Jayasri ; Kadish, Anna S. ; Klein, Sara ; Mikhail, Magdy ; Hagan, Robert J. ; Chang, Chee Jen ; Burk, Robert D. / Effects of β-carotene and other factors on outcome of cervical dysplasia and human papillomavirus infection. In: Gynecologic Oncology. 1997 ; Vol. 65, No. 3. pp. 483-492.
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AU - Kadish, Anna S.

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