@article{526b54e3f9934b2bbb5737c25e60cd23,
title = "Effectiveness of mRNA Vaccines Against COVID-19 Hospitalization by Age and Chronic Medical Conditions Burden Among Immunocompetent US Adults, March-August 2021",
abstract = "Vaccine effectiveness (VE) against COVID-19 hospitalization was evaluated among immunocompetent adults (≥18 years) during March-August 2021 using a case-control design. Among 1669 hospitalized COVID-19 cases (11% fully vaccinated) and 1950 RT-PCR-negative controls (54% fully vaccinated), VE was 96% (95% confidence interval [CI], 93%-98%) among patients with no chronic medical conditions and 83% (95% CI, 76%-88%) among patients with ≥ 3 categories of conditions. VE was similar between those aged 18-64 years versus ≥65 years (P >. 05). VE against severe COVID-19 was very high among adults without chronic conditions and lessened with increasing comorbidity burden.",
keywords = "COVID-19, chronic medical conditions, preexisting conditions, vaccine effectiveness",
author = "{IVY Network Collaborators} and Lewis, {Nathaniel M.} and Naioti, {Eric A.} and Self, {Wesley H.} and Ginde, {Adit A.} and Douin, {David J.} and {Keipp Talbot}, H. and Casey, {Jonathan D.} and Mohr, {Nicholas M.} and Anne Zepeski and Manjusha Gaglani and Ghamande, {Shekhar A.} and McNeal, {Tresa A.} and Shapiro, {Nathan I.} and Gibbs, {Kevin W.} and {Clark Files}, D. and Hager, {David N.} and Arber Shehu and Prekker, {Matthew E.} and Erickson, {Heidi L.} and Gong, {Michelle N.} and Amira Mohamed and Henning, {Daniel J.} and Steingrub, {Jay S.} and Peltan, {Ithan D.} and Brown, {Samuel M.} and Martin, {Emily T.} and Kinsley Hubel and Hough, {Catherine L.} and Busse, {Laurence W.} and {Ten Lohuis}, {Caitlin C.} and Abhijit Duggal and Wilson, {Jennifer G.} and Gordon, {Alexandra J.} and Nida Qadir and Chang, {Steven Y.} and Christopher Mallow and Carolina Rivas and Babcock, {Hilary M.} and Kwon, {Jennie H.} and Exline, {Matthew C.} and Natasha Halasa and Chappell, {James D.} and Lauring, {Adam S.} and Grijalva, {Carlos G.} and Rice, {Todd W.} and Rhoads, {Jillian P.} and Stubblefield, {William B.} and Adrienne Baughman and Chen, {Jen Ting Tina} and Hayley Gershengorn",
note = "Publisher Copyright: {\textcopyright} 2021 Published by Oxford University Press for the Infectious Diseases Society of America 2021.",
year = "2022",
month = may,
day = "15",
doi = "10.1093/infdis/jiab619",
language = "English (US)",
volume = "225",
pages = "1694--1700",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "10",
}
